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To address these challenges, we introduce a multifunctional surface modification strategy called targeting-specific interaction and blocking nonspecific adhesion (TAB) coating for flexible fiber, achieving a synergistic integration of mechanical compliance and biochemical stability. The coating combines brain-derived neurotrophic factor (BDNF) conjugation and a lubricant-infused surface. This dual-functional design enables selective interaction with neurons and astrocytes while preventing nonspecific adhesion. Notably, high-quality single-unit neural signals were stably recorded for more than 12 months after implantation, demonstrating exceptional long-term recording performance. Integrating mechanical compatibility, antifouling properties, and selective neural cell interaction, the TAB-coated multifunctional fiber represents a transformative approach for neural implants, bridging biological systems with computational systems.<\/jats:p>","DOI":"10.1126\/sciadv.adz1228","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T18:01:02Z","timestamp":1757527262000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":3,"title":["Bioadaptive liquid-infused multifunctional fibers for long-term neural recording via BDNF stabilization and enhanced neural interaction"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6483-128X","authenticated-orcid":true,"given":"Tae Young","family":"Kim","sequence":"first","affiliation":[{"name":"School of Electrical and Electronic Engineering, Yonsei University, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1467-5485","authenticated-orcid":true,"given":"Yeonzu","family":"Son","sequence":"additional","affiliation":[{"name":"Program of Brain and Cognitive Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5557-5605","authenticated-orcid":true,"given":"Keun-Young","family":"Yook","sequence":"additional","affiliation":[{"name":"School of Electrical and Electronic Engineering, Yonsei University, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9196-5029","authenticated-orcid":true,"given":"Dong Gyu","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Materials Engineering and Convergence Technology, Gyeongsang National University, 501 Jinju-daero, Jinju 52828, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Transdisciplinary Medicine, Seoul National University Hospital, Seoul 03080, Republic of Korea."},{"name":"Innovative Medical Technology Research Institute, Seoul National University Hospital, Seoul 03080, Republic of Korea."},{"name":"Department of Clinical Medical Sciences, Seoul National University College of Medicine, Seoul 03080. 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