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Adv."],"published-print":{"date-parts":[[2026,3,27]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Streptococcus suis<\/jats:italic>\n                    is a largely neglected but emerging bacterial zoonotic pathogen of global concern for animal welfare, antibiotic resistance development, and human health. No effective vaccines are now available. Here, we identified and characterized the function and structure of two cell wall polysaccharide variants in pathogenic\n                    <jats:italic toggle=\"yes\">S. suis<\/jats:italic>\n                    strains using genetic deletion and (heterologous) complementation, lectin staining, glycan composition analysis, and specialized NMR spectroscopy. Both glycan variants were anionic polymers that differed in the presence of glucose in the side chain as a result of allelic variation in a glycosyltransferase gene. Deletion of this variable glycosyltransferase revealed an identical glycan \u201ccore\u201d and affected\n                    <jats:italic toggle=\"yes\">S. suis<\/jats:italic>\n                    morphology and lysozyme resistance. Immunization of pigs with this core domain elicited antibodies that recognized antigenically diverse pathogenic\n                    <jats:italic toggle=\"yes\">S. suis<\/jats:italic>\n                    strains and induced complement deposition on encapsulated pathogenic\n                    <jats:italic toggle=\"yes\">S. suis<\/jats:italic>\n                    strains. This study provides valuable insights for developing next-generation glycoconjugate vaccines, whereby a single-glycan target could protect against the emerging zoonotic pathogen\n                    <jats:italic toggle=\"yes\">S. suis<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1126\/sciadv.adz1854","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T18:00:16Z","timestamp":1774461616000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":1,"title":["A conserved glycan motif induces broadly reactive functional antibodies against the zoonotic pathogen\n                    <i>Streptococcus suis<\/i>"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9628-5079","authenticated-orcid":true,"given":"Yao","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Population Health Sciences, Division Farm Animal Health, Utrecht University, Utrecht, Netherlands."},{"name":"Department of Medical Microbiology and Infection Prevention, Amsterdam UMC Location University of Amsterdam, Amsterdam, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8303-4481","authenticated-orcid":true,"given":"G\u00f6ran","family":"Widmalm","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Arrhenius Laboratory, Stockholm University, Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1999-6007","authenticated-orcid":true,"given":"Charlotte","family":"Sorieul","sequence":"additional","affiliation":[{"name":"Leiden Institute of Chemistry, Leiden University, Leiden, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0553-8734","authenticated-orcid":true,"given":"Thomas J.","family":"Roodsant","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Infection Prevention, Amsterdam UMC Location University of Amsterdam, Amsterdam, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey S.","family":"Rush","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Korotkova","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY, USA."},{"name":"Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, KY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5465-4515","authenticated-orcid":true,"given":"Manouk","family":"Vrieling","sequence":"additional","affiliation":[{"name":"Wageningen Bioveterinary Research, Houtribweg 39, Lelystad, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonius A. 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Coral","family":"Dom\u00ednguez-Medina","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Infection Prevention, Amsterdam UMC Location University of Amsterdam, Amsterdam, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6197-9861","authenticated-orcid":true,"given":"Irene M.","family":"Schimmel","sequence":"additional","affiliation":[{"name":"Electron Microscopy Center Amsterdam, Amsterdam UMC location University of Amsterdam, Amsterdam, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6392-3417","authenticated-orcid":true,"given":"Nicole N.","family":"van der Wel","sequence":"additional","affiliation":[{"name":"Electron Microscopy Center Amsterdam, Amsterdam UMC location University of Amsterdam, Amsterdam, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cameron W.","family":"Kenner","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, KY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1118-8953","authenticated-orcid":true,"given":"Christian","family":"Heiss","sequence":"additional","affiliation":[{"name":"Complex Carbohydrate Research Center, University of Georgia, Athens, GA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6166-9432","authenticated-orcid":true,"given":"Parastoo","family":"Azadi","sequence":"additional","affiliation":[{"name":"Complex Carbohydrate Research Center, University of Georgia, Athens, GA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3873-423X","authenticated-orcid":true,"given":"Li","family":"Tan","sequence":"additional","affiliation":[{"name":"Complex Carbohydrate Research Center, University of Georgia, Athens, GA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3531-2138","authenticated-orcid":true,"given":"Jeroen D. 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