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Using cell-specific knockout models, we show that deleting\n                    <jats:italic toggle=\"yes\">Chi3l1<\/jats:italic>\n                    in macrophages or\n                    <jats:italic toggle=\"yes\">Il13ra2<\/jats:italic>\n                    in HSCs markedly reduces liver inflammation and fibrosis. Furthermore, CHI3L1-neutralizing antibodies disrupt this circuit and significantly improve disease outcomes in mice. These findings uncover a complete IL-17A\u2013CHI3L1\u2013IL-13R\u03b12\u2013LCN2 signaling network, positioning CHI3L1 as both a mechanistic effector and a promising therapeutic target in MASH-fibrosis.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.adz3223","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T18:58:43Z","timestamp":1765393123000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":11,"title":["Decoding the CHI3L1\/IL-13R\u03b12 signaling nexus in MASH-fibrosis pathogenesis"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5906-148X","authenticated-orcid":true,"given":"Qianqian","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Pathophysiology, Basic Medicine College, China Medical University, Shenyang, 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