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Adv."],"published-print":{"date-parts":[[2025,12,5]]},"abstract":"<jats:p>\n                    Abdominal aortic aneurysm (AAA) is a life-threatening condition lacking effective drug interventions, and its progression is difficult to predict, complicating early clinical management. Here, we present a reactive oxygen species\u2013responsive theranostic nanozyme for AAA early intervention and efficacy monitoring, establishing a feedback loop between treatment and diagnostics. OZn, designed by encapsulating ultrasmall Prussian blue (SPBZn) within oxidation-sensitive dextran, targets aneurysm sites, where it responds to inflammatory microenvironments by releasing SPBZn. In vivo, SPBZn not only mitigated CaCl\n                    <jats:sub>2<\/jats:sub>\n                    -induced aneurysm expansion and AAA progression in rat models but also enabled noninvasive diagnostic monitoring via urinalysis due to its enzymatic activities and renal metabolism. This theranostic nanozyme dynamically regulated therapeutic efficacy and provided feedback on disease progression. By preventing vascular rupture through early intervention and enabling precise drug administration, this work highlights a transformative strategy for integrating diagnostics and therapy to improve AAA management and clinical outcomes.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.adz3713","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T18:59:02Z","timestamp":1764788342000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":14,"title":["An ultrasmall theranostic nanozyme for abdominal aortic aneurysm management and therapeutic efficacy monitoring"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-9481-2083","authenticated-orcid":true,"given":"Wanling","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, College of Engineering and Applied Sciences, Nanjing National Laboratory of Microstructures, Jiangsu Key Laboratory of Artificial Functional Materials, Nanjing University, Nanjing, Jiangsu 210023, P. R. China."},{"name":"Department of Cardiology, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing 400037, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0238-2124","authenticated-orcid":true,"given":"Yihong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, College of Engineering and Applied Sciences, Nanjing National Laboratory of Microstructures, Jiangsu Key Laboratory of Artificial Functional Materials, Nanjing University, Nanjing, Jiangsu 210023, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5594-9390","authenticated-orcid":true,"given":"Xiaomiao","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, College of Engineering and Applied Sciences, Nanjing National Laboratory of Microstructures, Jiangsu Key Laboratory of Artificial Functional Materials, Nanjing University, Nanjing, Jiangsu 210023, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3613-2774","authenticated-orcid":true,"given":"Qi","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, College of Engineering and Applied Sciences, Nanjing National Laboratory of Microstructures, Jiangsu Key Laboratory of Artificial Functional Materials, Nanjing University, Nanjing, Jiangsu 210023, P. R. 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China."},{"name":"State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Centre (ChemBIC), ChemBioMed Interdisciplinary Research Centre at Nanjing University, Nanjing University, Nanjing, Jiangsu 210023, P. R. China."},{"name":"Nanozyme Laboratory in Zhongyuan, Henan Academy of Innovations in Medical Science, Zhengzhou, Henan 451163, P. R. China."},{"name":"NMPA Key Laboratory for Biomedical Optics, Hangzhou, Zhejiang 310018, P. R. 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