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We find that IHCs promote or induce the (i) differentiation of one SC type (outer pillar) at the expense of another (Deiters\u2019), so that each completely and exclusively populates separate rows; (ii) packing density, but not identity, of inner pillar cells; and (iii) embryonic formation and (iv) cytoplasmic attraction of adjacent inner phalangeal cells, which envelop IHCs. Hence, developing IHCs dictate major aspects of SC identity and distribution to assemble the complex organ of Corti.<\/jats:p>","DOI":"10.1126\/sciadv.adz3944","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T17:58:36Z","timestamp":1761760716000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":3,"title":["Targeted cell interconversions reveal inner hair cell control of organ of Corti cytoarchitecture"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3580-0986","authenticated-orcid":true,"given":"Ignacio","family":"Garc\u00eda-G\u00f3mez","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9163-9309","authenticated-orcid":true,"given":"Jemma L.","family":"Webber","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3538-7376","authenticated-orcid":true,"given":"Berta","family":"Soria-Izquierdo","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2867-9740","authenticated-orcid":true,"given":"John C.","family":"Clancy","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4922-289X","authenticated-orcid":true,"given":"Anne","family":"Duggan","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA."},{"name":"Hugh Knowles Center for Clinical and Basic Science in Hearing and its Disorders, Northwestern University, Evanston, IL, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingjie","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA."},{"name":"Department of Communication Sciences and Disorders, Northwestern University, Evanston, IL, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0663-0428","authenticated-orcid":true,"given":"Charles P.","family":"Murphey","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA."},{"name":"Interdepartmental Neuroscience Graduate Program, Northwestern University, Chicago, IL, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2405-9857","authenticated-orcid":true,"given":"Trevor D. 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