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Adv."],"published-print":{"date-parts":[[2025,12,12]]},"abstract":"<jats:p>\n                    Cell death is an integral restriction mechanism against intracellular pathogens. We have previously reported extensive cell death in the brain during infection with the intracellular parasite,\n                    <jats:italic toggle=\"yes\">Toxoplasma gondii.<\/jats:italic>\n                    Here, we focus on the role of caspase-8, a regulator of extrinsic apoptosis, during\n                    <jats:italic toggle=\"yes\">T. gondii<\/jats:italic>\n                    infection. We find that\n                    <jats:italic toggle=\"yes\">\n                      Casp8\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      Ripk3\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    mice have increased brain parasite burden in comparison to controls and succumb to infection despite the generation of robust immune responses. We observed that neurons, astrocytes, and CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells had high rates of parasite interactions in\n                    <jats:italic toggle=\"yes\">\n                      Casp8\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      Ripk3\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    mice compared to wild-type mice. While\n                    <jats:italic toggle=\"yes\">Casp8<\/jats:italic>\n                    deficiency in neurons and astrocytes did not affect control of infection, deletion of\n                    <jats:italic toggle=\"yes\">Casp8<\/jats:italic>\n                    in CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells led to impaired survival, increased parasite burden, and direct infection of CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells in the brain. We conclude that in addition to well-characterized effector functions, CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells use caspase-8 to control\n                    <jats:italic toggle=\"yes\">T. gondii<\/jats:italic>\n                    in the brain.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.adz4468","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T18:58:57Z","timestamp":1765565937000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":1,"title":["Caspase-8 expression in CD8\n                    <sup>+<\/sup>\n                    T cells promotes pathogen restriction in the brain during\n                    <i>Toxoplasma gondii<\/i>\n                    infection"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6364-7448","authenticated-orcid":true,"given":"Lydia 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