{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T18:52:00Z","timestamp":1781722320459,"version":"3.54.5"},"reference-count":62,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"25","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32070642"],"award-info":[{"award-number":["32070642"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31371222"],"award-info":[{"award-number":["31371222"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Key Research and Development Program from Ministry of Science and Technology of China","award":["2017YFD0300100"],"award-info":[{"award-number":["2017YFD0300100"]}]},{"name":"The National Key Research and Development Program from Ministry of Science and Technology of China","award":["2016YFD0100400"],"award-info":[{"award-number":["2016YFD0100400"]}]}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2026,6,19]]},"abstract":"<jats:p>\n                    Flowering time of rice (\n                    <jats:italic toggle=\"yes\">Oryza sativa<\/jats:italic>\n                    ) plays important roles in regulating grain yield, quality, and adaptability.\n                    <jats:italic toggle=\"yes\">O. sativa<\/jats:italic>\n                    GIGANTEAN (OsGI), heading date 1 (Hd1), and\n                    <jats:italic toggle=\"yes\">O. sativa<\/jats:italic>\n                    flavin-binding, Kelch repeat, and F-box 1 (OsFKF1) are key factors controlling flowering time in rice. However, their relationships are not quite clear. In this study, we found that OsFKF1, an F-box domain\u2013containing protein, physically interacts with OsGI and Hd1. OsFKF1 targets OsGI for degradation through ubiquitination-mediated 26\n                    <jats:italic toggle=\"yes\">S<\/jats:italic>\n                    proteasome. OsFKF1 is functionally conserved with FKF1 in\n                    <jats:italic toggle=\"yes\">Arabidopsis<\/jats:italic>\n                    . Mutations of\n                    <jats:italic toggle=\"yes\">OsFKF1<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">OsGI<\/jats:italic>\n                    , and\n                    <jats:italic toggle=\"yes\">Hd1<\/jats:italic>\n                    generated through CRISPR-Cas9 in the same genetic background confer late flowering phenotypes. The\n                    <jats:italic toggle=\"yes\">osfkf1<\/jats:italic>\n                    mutations suppress the expression of\n                    <jats:italic toggle=\"yes\">Ehd1<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">Hd1<\/jats:italic>\n                    , and\n                    <jats:italic toggle=\"yes\">Ehd2<\/jats:italic>\n                    , while activating\n                    <jats:italic toggle=\"yes\">Ghd7<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">Ehd3<\/jats:italic>\n                    , which further reduces the expression of florigen genes\n                    <jats:italic toggle=\"yes\">Hd3a<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">RFT1<\/jats:italic>\n                    , leading to delayed flowering time. Mutations of\n                    <jats:italic toggle=\"yes\">OsFKF1<\/jats:italic>\n                    also affect the agronomic traits and enhance grain yield. These findings reveal the molecular mechanisms of OsFKF1 on regulating flowering time and provide valuable germplasm resources for rice breeding to improve growth period.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.adz5090","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T18:00:26Z","timestamp":1781719226000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":0,"title":["An F-box protein OsFKF1 interacts with either OsGI or Hd1 and mediates the degradation of OsGI to control flowering time in rice"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6949-1424","authenticated-orcid":true,"given":"Xinfeng","family":"Zhang","sequence":"first","affiliation":[{"name":"Rice Research Institute, Shenyang Agricultural University, Shenyang 110866, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9659-8868","authenticated-orcid":true,"given":"Yiqiong","family":"Huo","sequence":"additional","affiliation":[{"name":"Rice Research Institute, Shenyang Agricultural University, Shenyang 110866, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0932-4071","authenticated-orcid":true,"given":"Yanjuan","family":"Hu","sequence":"additional","affiliation":[{"name":"Rice Research Institute, Shenyang Agricultural University, Shenyang 110866, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4362-8677","authenticated-orcid":true,"given":"Tianqiong","family":"Wang","sequence":"additional","affiliation":[{"name":"Rice Research Institute, Shenyang Agricultural University, Shenyang 110866, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2878-4911","authenticated-orcid":true,"given":"Yanbin","family":"Yin","sequence":"additional","affiliation":[{"name":"Rice Research Institute, Shenyang Agricultural University, Shenyang 110866, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2452-0871","authenticated-orcid":true,"given":"Yanpeng","family":"Lyu","sequence":"additional","affiliation":[{"name":"Rice Research Institute, Shenyang Agricultural University, Shenyang 110866, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqi","family":"Yang","sequence":"additional","affiliation":[{"name":"Rice Research Institute, Shenyang Agricultural University, Shenyang 110866, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8726-242X","authenticated-orcid":true,"given":"Bowen","family":"Yan","sequence":"additional","affiliation":[{"name":"Rice Research Institute, Shenyang Agricultural University, Shenyang 110866, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8601-7505","authenticated-orcid":true,"given":"Zhibo","family":"Cui","sequence":"additional","affiliation":[{"name":"Rice Research Institute, Shenyang Agricultural University, Shenyang 110866, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1012-8246","authenticated-orcid":true,"given":"Xiaoxue","family":"Wang","sequence":"additional","affiliation":[{"name":"Rice Research Institute, Shenyang Agricultural University, Shenyang 110866, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/nph.17158"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/jxb\/erae209"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-arplant-043014-115555"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbi.2013.01.005"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21165871"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.008631"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1141753"},{"key":"e_1_3_2_9_2","first-page":"1576","article-title":"Genomic survey of PEBP gene family in rice: Identification, phylogenetic analysis, and expression profiles in organs and under abiotic stresses","volume":"11","author":"Zhao C.","year":"2022","unstructured":"C. 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