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Adv."],"published-print":{"date-parts":[[2025,12,19]]},"abstract":"<jats:p>\n                    To overcome limitations of flexible thermoacoustic devices in low-frequency emission and sensing, we present a resonance-adjustable graphene sound device (RAGSD) inspired by frog vocal sacs. Integrating laser-induced graphene (LIG) with a deformable cavity, RAGSD provides continuous tuning from 922.12 to 1762.90\u00a0hertz. A dynamic, continuously tunable electro-mechano-acoustical model explains the mechanism and predicts frequency with\n                    <jats:inline-formula>\n                      <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" display=\"inline\" overflow=\"scroll\">\n                        <mml:mrow>\n                          <mml:msup>\n                            <mml:mi>R<\/mml:mi>\n                            <mml:mn>2<\/mml:mn>\n                          <\/mml:msup>\n                          <mml:mo>=<\/mml:mo>\n                          <mml:mn>0.990<\/mml:mn>\n                        <\/mml:mrow>\n                      <\/mml:math>\n                    <\/jats:inline-formula>\n                    \u200a. In emission, a 25.34-decibel sound pressure level gain was observed at resonance, enabling controllable, frequency-selective voice amplification for personalized output. In sensing, the LIG piezoresistive readout delivers sensitive transduction, while resonance matching amplifies weak, high-frequency cardiac sounds. Wearable tests on healthy volunteers and patients recorded clear S1\/S2 and pathological murmurs. Integrated with AuscNet-H, a deep learning algorithm designed for heart sound classification, the system achieved 99.375% accuracy across four clinical classes. Under inflation, no false negatives occurred, and misclassifications among similar diseases were fewer than with a commercial electronic stethoscope. These results demonstrate a practical path toward intelligent, wearable auscultation.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.adz5930","type":"journal-article","created":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T18:59:52Z","timestamp":1765997992000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":7,"title":["Frog vocal sacs-inspired soft acoustic system with continuously tunable resonance for sound emission and stethoscopic sensing"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6810-3634","authenticated-orcid":true,"given":"Chuting","family":"Liu","sequence":"first","affiliation":[{"name":"School of Biomedical Engineering, Shenzhen Campus of Sun Yat-sen University, No. 66, Gongchang Road, Guangming District, Shenzhen, Guangdong 518107, China."},{"name":"Key Laboratory of Sensing Technology and Biomedical Instruments of Guangdong Province, School of Biomedical 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