{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T19:52:04Z","timestamp":1793476324340,"version":"4.5.0"},"reference-count":56,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"15","funder":[{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"publisher","award":["883703"],"award-info":[{"award-number":["883703"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP\/L015978\/1"],"award-info":[{"award-number":["EP\/L015978\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP\/L027151\/1"],"award-info":[{"award-number":["EP\/L027151\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP\/X037770\/1"],"award-info":[{"award-number":["EP\/X037770\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["101212602"],"award-info":[{"award-number":["101212602"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University of Cambridge Harding Distinguished Postgraduate Scholars Programme"},{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP\/L015889\/1"],"award-info":[{"award-number":["EP\/L015889\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP\/L015889\/1"],"award-info":[{"award-number":["EP\/L015889\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"name":"AstraZeneca"},{"DOI":"10.13039\/501100005370","name":"Gates Cambridge Trust","doi-asserted-by":"publisher","award":["OPP1144"],"award-info":[{"award-number":["OPP1144"]}],"id":[{"id":"10.13039\/501100005370","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["UKRI1255"],"award-info":[{"award-number":["UKRI1255"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"name":"AstraZeneca"},{"DOI":"10.13039\/501100000288","name":"Royal Society","doi-asserted-by":"publisher","award":["URF\\R1\\211162"],"award-info":[{"award-number":["URF\\R1\\211162"]}],"id":[{"id":"10.13039\/501100000288","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP\/Y008294\/1"],"award-info":[{"award-number":["EP\/Y008294\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2026,4,10]]},"abstract":"<jats:p>\n                    Robust real-time gas sensing is important for many fields, including agriculture and health care analysis of breath\/biofluid volatiles. Ammonia is ambiently present at parts per billion (ppb) to parts per million (ppm) levels, but current detection technologies suffer long measurement times, instability, cost, and issues with selectivity. Here, surface-enhanced Raman spectroscopy (SERS) is markedly improved through precision precleaning protocols, which allow surface sensitization of the metal facets using a water monolayer. Harnessing monolayer aggregates of densely packed gold nanoparticles with sub-nanometer spacing defined by rigid scaffolding molecules gives sub-ppm detection of ammonia at room temperature. Accessing the poorly studied high\u2013wave number [&gt;2500 per centimeter (cm\n                    <jats:sup>\u22121<\/jats:sup>\n                    )] region provides much improved discriminatory capabilities, enabling us to generalize this approach to a range of volatile organic carbon (VOC) molecules including ethanol, methanol, and acetone.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.aea1478","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T18:00:23Z","timestamp":1775671223000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":3,"title":["The optical nose: Monolayer sensitization of Au surfaces for plasmonic gas sensing"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5372-8217","authenticated-orcid":true,"given":"Elle W.","family":"Wyatt","sequence":"first","affiliation":[{"name":"NanoPhotonics Centre, Cavendish Laboratory, Department of Physics, JJ Thompson Avenue, University of Cambridge, Cambridge CB3 0US, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6015-4090","authenticated-orcid":true,"given":"Sarah May","family":"Sibug-Torres","sequence":"additional","affiliation":[{"name":"NanoPhotonics Centre, Cavendish Laboratory, Department of Physics, JJ Thompson Avenue, University of Cambridge, Cambridge CB3 0US, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marika","family":"Niihori","sequence":"additional","affiliation":[{"name":"NanoPhotonics Centre, Cavendish Laboratory, Department of Physics, JJ Thompson Avenue, University of Cambridge, Cambridge CB3 0US, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4028-0150","authenticated-orcid":true,"given":"James W.","family":"Beattie","sequence":"additional","affiliation":[{"name":"NanoPhotonics Centre, Cavendish Laboratory, Department of Physics, JJ Thompson Avenue, University of Cambridge, Cambridge CB3 0US, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7864-2263","authenticated-orcid":true,"given":"Tabitha","family":"Jones","sequence":"additional","affiliation":[{"name":"NanoPhotonics Centre, Cavendish Laboratory, Department of Physics, JJ Thompson Avenue, University of Cambridge, Cambridge CB3 0US, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8131-5230","authenticated-orcid":true,"given":"Nicolas","family":"Spiesshofer","sequence":"additional","affiliation":[{"name":"NanoPhotonics Centre, Cavendish Laboratory, Department of Physics, JJ Thompson Avenue, University of Cambridge, Cambridge CB3 0US, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7716-0333","authenticated-orcid":true,"given":"Jana","family":"Hofmann","sequence":"additional","affiliation":[{"name":"NanoPhotonics Centre, Cavendish Laboratory, Department of Physics, JJ Thompson Avenue, University of Cambridge, Cambridge CB3 0US, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8234-723X","authenticated-orcid":true,"given":"Bart","family":"de Nijs","sequence":"additional","affiliation":[{"name":"Physics for Sustainable Chemistry Group, Department of Physics, JJ Thompson Avenue, University of Cambridge, Cambridge CB3 0US, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9606-9488","authenticated-orcid":true,"given":"Jeremy J.","family":"Baumberg","sequence":"additional","affiliation":[{"name":"NanoPhotonics Centre, Cavendish Laboratory, Department of Physics, JJ Thompson Avenue, University of Cambridge, Cambridge CB3 0US, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","unstructured":"L. D. Lehman-McKeeman \u201cAbsorption distribution and excretion of toxicants \u201d in Casarett & Doull\u2019s Essentials of Toxicology Third Edition (McGraw-Hill Education 2015)."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1149\/2.F05104if"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1039\/C9TB02518A"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40291-023-00640-7"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.microc.2004.10.008"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2011.03.011"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0178745"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1088\/0967-3334\/27\/4\/001"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1997.324"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bj.2023.100623"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/bit.10141"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2005.06.064"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2004.12.108"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jenvman.2022.116285"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsenergylett.0c02219"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.56530\/lcgc.na.yn3065q6"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2006.05.008"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2006.05.006"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2019.06.034"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1039\/D2SD00089J"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adp1764"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac053456d"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b04224"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2020.101757"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/jrs.881"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1364\/OE.437979"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1021\/acssensors.3c00967"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-46097-y"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202302531"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202507013"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1039\/C8CC00564H"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-15135-4"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-2481(01)00156-4"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xpro.2021.100599"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matpr.2020.05.421"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.0c02752"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/jrs.6008"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms5348"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1039\/D2CP03375E"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03046550"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201704162"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.1352"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.3390\/s20247024"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13615-2"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-7516(99)00046-0"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1039\/C8FD00155C"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c16452"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja01447a003"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1021\/jp991696p"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1021\/j100357a041"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1039\/C7CP06943J"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja01690a020"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja01388a004"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9614(70)90038-8"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja01253a021"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19703-y"}],"container-title":["Science Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciadv.aea1478","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T20:40:22Z","timestamp":1776285622000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciadv.aea1478"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,10]]},"references-count":56,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2026,4,10]]}},"alternative-id":["10.1126\/sciadv.aea1478"],"URL":"https:\/\/doi.org\/10.1126\/sciadv.aea1478","relation":{},"ISSN":["2375-2548"],"issn-type":[{"value":"2375-2548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,10]]},"assertion":[{"value":"2025-07-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eaea1478"}}