{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T12:28:54Z","timestamp":1791462534424,"version":"4.3.4"},"reference-count":41,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"28","funder":[{"DOI":"10.13039\/100004410","name":"European Molecular Biology Organization","doi-asserted-by":"publisher","award":["SYCE2"],"award-info":[{"award-number":["SYCE2"]}],"id":[{"id":"10.13039\/100004410","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["219413\/Z\/19\/Z"],"award-info":[{"award-number":["219413\/Z\/19\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000357","name":"North West Cancer Research Fund","doi-asserted-by":"publisher","award":["RDG2021.15 and CD2019.14 and NWCRLAN2024.01"],"award-info":[{"award-number":["RDG2021.15 and CD2019.14 and NWCRLAN2024.01"]}],"id":[{"id":"10.13039\/501100000357","id-type":"DOI","asserted-by":"publisher"}]},{"name":"MRC","award":["MR\/X00855X\/1 as well as grant number DTP2"],"award-info":[{"award-number":["MR\/X00855X\/1 as well as grant number DTP2"]}]},{"DOI":"10.13039\/501100001349","name":"Singapore National Medical Research Council","doi-asserted-by":"crossref","award":["NMRC\/OFIRG21nov-0027 and OFIRG24jul-0094"],"award-info":[{"award-number":["NMRC\/OFIRG21nov-0027 and OFIRG24jul-0094"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"crossref"}]},{"name":"A*STAR Biomedical Research Council","award":["WWT"],"award-info":[{"award-number":["WWT"]}]},{"name":"European Molecular Biology Organization Young Investigator Network Grant","award":["IG5333"],"award-info":[{"award-number":["IG5333"]}]},{"name":"NCN Sonata Bis","award":["2023\/50\/E\/NZ3\/00281"],"award-info":[{"award-number":["2023\/50\/E\/NZ3\/00281"]}]},{"name":"Central Research Fund, Use-Inspired Basic Research","award":["CRF UIBR"],"award-info":[{"award-number":["CRF UIBR"]}]},{"name":"Singapore National Research Foundation Competitive Research Programme","award":["NRF-CRP31-0024"],"award-info":[{"award-number":["NRF-CRP31-0024"]}]},{"name":"Light Microscopy Core of the Wellcome Discovery Research Platform for Hidden Cell Biology"}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2026,7,10]]},"abstract":"<jats:p>\n                    Maintenance of genome integrity is essential for cellular homeostasis, and its perturbation leads to tumorigenesis. Here, we uncover an unanticipated somatic role for the synaptonemal complex protein SYCP1, previously regarded as strictly meiosis specific, in a broad spectrum of human cancers including breast cancer. Through integrative genomic, proteomic, and functional analyses, we demonstrate that SYCP1 is aberrantly reexpressed in tumor cells, where it actively promotes DNA damage repair, cell cycle progression, and malignant growth. SYCP1 binds chromatin at regulatory elements and directly controls transcriptional programs governing genome maintenance, including key effectors such as\n                    <jats:italic toggle=\"yes\">CCNB1<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">PCNA<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">RAD51C<\/jats:italic>\n                    , and\n                    <jats:italic toggle=\"yes\">H2AX<\/jats:italic>\n                    . Loss of SYCP1 impairs DNA repair kinetics, attenuates tumor cell proliferation and migration, and increases sensitivity to chemotherapeutics cisplatin and gemcitabine. Mechanistically, SYCP1 coimmunoprecipitates with chromatin remodeling complexes and transcription factors SP1 and SP2 and modulates their genomic occupancy and oncogenic transcriptional outputs. Clinically, high SYCP1 expression stratifies patients with poor prognosis and therapy resistance across multiple cancer types. Our findings illuminate a previously unrecognized moonlighting function of SYCP1 in somatic cancer cells and position it as a critical chromatin-associated regulator of genome stability, with implications for biomarker development and therapeutic targeting.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.aea2067","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T18:00:55Z","timestamp":1783533655000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":2,"title":["Moonlighting role of meiotic SYCP1 in breast cancer: A chromatin-bound regulator of DNA repair, transcription, and drug resistance"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0324-2665","authenticated-orcid":true,"given":"Louise C.","family":"Brennan","sequence":"first","affiliation":[{"name":"Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Crown Street, Liverpool, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0746-2705","authenticated-orcid":true,"given":"Oleg V.","family":"Grinchuk","sequence":"additional","affiliation":[{"name":"Chromatin Dynamics and Disease Epigenetics Lab, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), 61 Biopolis Drive, Proteos, Singapore 138673, Republic of Singapore."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Pachon-Penalba","sequence":"additional","affiliation":[{"name":"Centre for Cell Biology, Institute of Cell Biology, University of Edinburgh, Michael Swann Building, Max Born Crescent, Edinburgh, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ieng F.","family":"Sou","sequence":"additional","affiliation":[{"name":"Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Crown Street, Liverpool, UK."},{"name":"Chromatin Dynamics and Disease Epigenetics Lab, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), 61 Biopolis Drive, Proteos, Singapore 138673, Republic of Singapore."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0057-983X","authenticated-orcid":true,"given":"Conor J.","family":"Fawcett","sequence":"additional","affiliation":[{"name":"Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Crown Street, Liverpool, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4230-0808","authenticated-orcid":true,"given":"Claudia G.","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Institute of Medical Biology, Polish Academy of Sciences, Tylna 3A, Lodz, Poland."},{"name":"Bio-Med-Chem Doctoral School of the University of Lodz and Lodz Institutes of the Polish Academy of Sciences, 90-237 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