{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:40:59Z","timestamp":1791560459401,"version":"4.3.4"},"reference-count":47,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"51","funder":[{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["874708"],"award-info":[{"award-number":["874708"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["FRM project number R22108BB"],"award-info":[{"award-number":["FRM project number R22108BB"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2025,12,19]]},"abstract":"<jats:p>\n                    Lymphedema is a lymphatic dysfunction leading to an accumulation of fluid and fat in the arm or leg. Here, we performed noncoding RNA profiling of human breast cancer\u2013induced secondary lymphedema. We identified the long intergenic non\u2013protein coding RNA, P53-induced transcript (\n                    <jats:italic toggle=\"yes\">LINC-PINT<\/jats:italic>\n                    ), as essential for the lymphedema development.\n                    <jats:italic toggle=\"yes\">LINC-PINT<\/jats:italic>\n                    is the most expressed lncRNA in human lymphatic endothelial cells (LECs) under stress condition. Knocking down\n                    <jats:italic toggle=\"yes\">LINC-PINT<\/jats:italic>\n                    in LECs promotes the expression of inflammation-related genes. Mechanistically, ATAC-seq revealed that\n                    <jats:italic toggle=\"yes\">LINC-PINT<\/jats:italic>\n                    induces the transcription of genes involved in lymphangiogenesis and immune cell adhesion by increasing chromatin accessibility. Notably,\n                    <jats:italic toggle=\"yes\">LINC-PINT<\/jats:italic>\n                    deficiency impairs LEC proliferation, migration, and sprouting. Conditional deletion of\n                    <jats:italic toggle=\"yes\">Lnc-Pint<\/jats:italic>\n                    in mouse lymphatic endothelium (Lnc-Pint\n                    <jats:sup>lecko<\/jats:sup>\n                    ) leads to a reduction in dermal lymphatic network density. Lnc-Pint\n                    <jats:sup>lecko<\/jats:sup>\n                    mice exhibit decreased lymphedema, reduced dermal backflow, fibrosis, and inflammation. Our findings unveil a crucial molecular role of\n                    <jats:italic toggle=\"yes\">LINC-PINT<\/jats:italic>\n                    in lymphatic function and hold substantial clinical implications for lncRNA as biomarker of lymphedema.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.aea2960","type":"journal-article","created":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T18:59:52Z","timestamp":1765997992000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":3,"title":["lncRNA LINC-PINT controls lymphatic function and inflammatory profile in lymphedema"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1288-0263","authenticated-orcid":true,"given":"Nathalie","family":"Laugero","sequence":"first","affiliation":[{"name":"I2MC, Universit\u00e9 de Toulouse, Inserm UMR 1297, Toulouse, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3304-3018","authenticated-orcid":true,"given":"Claire","family":"Peghaire","sequence":"additional","affiliation":[{"name":"I2MC, Universit\u00e9 de Toulouse, Inserm UMR 1297, Toulouse, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e9na","family":"Verdu","sequence":"additional","affiliation":[{"name":"I2MC, Universit\u00e9 de Toulouse, Inserm UMR 1297, Toulouse, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9689-0390","authenticated-orcid":true,"given":"Elisa","family":"Balzan","sequence":"additional","affiliation":[{"name":"I2MC, Universit\u00e9 de Toulouse, Inserm UMR 1297, Toulouse, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5518-6170","authenticated-orcid":true,"given":"Tangra","family":"Draia-Nicolau","sequence":"additional","affiliation":[{"name":"I2MC, Universit\u00e9 de Toulouse, Inserm UMR 1297, Toulouse, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxane","family":"Sylvestre","sequence":"additional","affiliation":[{"name":"I2MC, Universit\u00e9 de Toulouse, Inserm UMR 1297, Toulouse, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9836-5029","authenticated-orcid":true,"given":"Julie","family":"Malloizel-Delaunay","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Vasculaire, Centre Hospitalier Universitaire de Toulouse, Toulouse, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Bura-Rivi\u00e8re","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Vasculaire, Centre Hospitalier Universitaire de Toulouse, Toulouse, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1532-3665","authenticated-orcid":true,"given":"Florent","family":"Morfoisse","sequence":"additional","affiliation":[{"name":"I2MC, Universit\u00e9 de Toulouse, Inserm UMR 1297, Toulouse, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5282-3776","authenticated-orcid":true,"given":"Anne-Catherine","family":"Prats","sequence":"additional","affiliation":[{"name":"I2MC, Universit\u00e9 de Toulouse, Inserm UMR 1297, Toulouse, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1234-5260","authenticated-orcid":true,"given":"Eric","family":"Lacazette","sequence":"additional","affiliation":[{"name":"I2MC, Universit\u00e9 de Toulouse, Inserm UMR 1297, Toulouse, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6100-2294","authenticated-orcid":true,"given":"Barbara","family":"Garmy-Susini","sequence":"additional","affiliation":[{"name":"I2MC, Universit\u00e9 de Toulouse, Inserm UMR 1297, Toulouse, 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