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Adv."],"published-print":{"date-parts":[[2026,5,8]]},"abstract":"<jats:p>Real-time biomarker sensing and molecular sampling in the stomach can transform how gastrointestinal disorders are diagnosed and managed\u2014yet integrating both capabilities into a single ingestible platform remains a formidable challenge. Existing devices often struggle with size constraints, limited functionality, and the mechanical mismatch between soft, biocompatible materials and rigid electronics. Here, we present SeroTab, an electronics-free soft robotic minitablet that combines real-time pH sensing with on-demand gastric fluid sampling in vivo. Inspired by the gliding motion of penguins through viscous environments, SeroTab features a magnetically actuated, curvature-adaptive body that enables autonomous navigation through complex anatomical geometries to specific gastric regions. Upon reaching its target, a shape memory polymer actuator\u2014triggered wirelessly via radio frequency heating\u2014draws gastric fluid into an internal reservoir (up to 35 microliters). A pH-sensitive hydrogel within the chamber, embedded with biocompatible metal disks, enables ultrasound-based pH readout across a physiologically relevant range (pH 2 to 7) and preserves the sample for untargeted metabolomic profiling. In vivo studies in animal models demonstrate SeroTab\u2019s ability to detect pharmacologically induced pH changes (\u0394pH = 4, from 2 to 6) and metabolic shifts (42 detected metabolites) following omeprazole administration. By uniting soft robotics, responsive materials, and wireless actuation, SeroTab paves the way for minimally invasive, outpatient-compatible diagnostics that can advance early screening and streamline clinical decision-making.<\/jats:p>","DOI":"10.1126\/sciadv.aea3309","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T09:53:19Z","timestamp":1778579599000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":3,"title":["Electronics-free soft robotic minitablet for on-demand gastric molecular sensing and diagnostics in vivo"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1976-6431","authenticated-orcid":true,"given":"Chen","family":"Wang","sequence":"first","affiliation":[{"name":"Surgical Robotics Lab, Department of Biomaterials and Biomedical Technology, University Medical Center Groningen, University of Groningen, Groningen 9713 AV, 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Fudan University, Shanghai 200438, China."},{"name":"Zhejiang Key Laboratory of Extreme Environment Functional Materials, Yiwu Research Institute of Fudan University, Yiwu, Zhejiang 322000, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8724-7684","authenticated-orcid":true,"given":"Zongwei","family":"Cai","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Environmental and Biological Analysis, Hong Kong Baptist University, Hong Kong SAR 999077, China."},{"name":"Eastern Institute of Technology, Ningbo 315200, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2294-7487","authenticated-orcid":true,"given":"Xiang-zhong","family":"Chen","sequence":"additional","affiliation":[{"name":"International Institute of Intelligent Nanorobots and Nanosystem, College of Intelligent Robotics and, Advanced Manufacturing, Fudan University, Shanghai 200438, 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