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Adv."],"published-print":{"date-parts":[[2025,12,12]]},"abstract":"<jats:p>\n                    Schistosomes, parasitic flatworms responsible for the neglected tropical disease schistosomiasis, are protected by a skin-like tegument, and tegument maintenance is controlled by a schistosome ortholog (\n                    <jats:italic toggle=\"yes\">p53-1<\/jats:italic>\n                    ) of the tumor suppressor TP53. To understand\n                    <jats:italic toggle=\"yes\">p53-1<\/jats:italic>\n                    function, we characterized a schistosome cyclin-dependent kinase inhibitor homolog (\n                    <jats:italic toggle=\"yes\">cki<\/jats:italic>\n                    ). Knockdown of\n                    <jats:italic toggle=\"yes\">cki<\/jats:italic>\n                    resulted in hyperproliferation that, combined with\n                    <jats:italic toggle=\"yes\">p53-1<\/jats:italic>\n                    knockdown, yielded tumor-like growths, indicating that\n                    <jats:italic toggle=\"yes\">cki<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">p53-1<\/jats:italic>\n                    are tumor suppressors in\n                    <jats:italic toggle=\"yes\">Schistosoma mansoni<\/jats:italic>\n                    .\n                    <jats:italic toggle=\"yes\">cki<\/jats:italic>\n                    homologs are ubiquitous in parasitic flatworms but are absent from their free-living ancestors, suggesting that\n                    <jats:italic toggle=\"yes\">cki<\/jats:italic>\n                    may have come from horizontal gene transfer. This suggests that the evolution of parasitism in flatworms was aided by an unusual means of metazoan genetic inheritance.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.aea4905","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T18:58:43Z","timestamp":1765393123000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":1,"title":["Unusual inheritance of a functional\n                    <i>cki<\/i>\n                    homolog in the human pathogen\n                    <i>Schistosoma mansoni<\/i>"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8302-079X","authenticated-orcid":true,"given":"George R.","family":"Wendt","sequence":"first","affiliation":[{"name":"Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5237-1004","authenticated-orcid":true,"suffix":"III","given":"James J.","family":"Collins","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX, USA."},{"name":"Howard Hughes Medical Institute, Chevy Chase, MD, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.05503"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2021.11.002"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.12473"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.33221"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2205201119"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.044297"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2017.08.030"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-022-00988-z"},{"key":"e_1_3_2_10_2","first-page":"1169","article-title":"WAF1\/CIP1 is induced in p53-mediated G1 arrest and apoptosis","volume":"54","author":"El-Deiry W. S.","year":"1994","unstructured":"W. S. El-Deiry, J. W. Harper, P. M. O\u2019Connor, V. E. Velculescu, C. E. Canman, J. Jackman, J. A. Pietenpol, M. Burrell, D. E. Hill, Y. Wang, K. G. Wiman, W. E. Mercer, M. B. Kastan, K. W. Kohn, S. J. Elledge, K. W. Kinzler, B. Vogelstein, WAF1\/CIP1 is induced in p53-mediated G1 arrest and apoptosis. 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