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Vaccination of older adults with the adjuvanted vaccine did not restore CD8\n                    <jats:sup>+<\/jats:sup>\n                    defects but selectively enhanced T helper 17 (T\n                    <jats:sub>H<\/jats:sub>\n                    17) CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells and prevented their conversion into regulatory T cells, likely through lipid metabolic regulation. Thus, durable vaccine efficacy with aging relies on antigen-specific T\n                    <jats:sub>H<\/jats:sub>\n                    17 cells that compensate for CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell defects.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.aea7131","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T18:59:10Z","timestamp":1770404350000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":5,"title":["Antigen-specific T\n                    <sub>H<\/sub>\n                    17 cells offset the age-related decline in durable T cell immunity"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1272-5618","authenticated-orcid":true,"given":"Ines","family":"Sturmlechner","sequence":"first","affiliation":[{"name":"Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA."},{"name":"Robert and Arlene 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