{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:18:56Z","timestamp":1792009136860,"version":"4.4.0"},"reference-count":43,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"12","funder":[{"DOI":"10.13039\/100010269","name":"Wellcome","doi-asserted-by":"publisher","award":["316017\/Z\/24\/Z"],"award-info":[{"award-number":["316017\/Z\/24\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000691","name":"Academy of Medical Sciences","doi-asserted-by":"publisher","award":["SBF007\\100173"],"award-info":[{"award-number":["SBF007\\100173"]}],"id":[{"id":"10.13039\/501100000691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["NMRC\/OFIRG\/0049\/2017"],"award-info":[{"award-number":["NMRC\/OFIRG\/0049\/2017"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Academy of Medical Sciences and the Springboard Award scheme funders: the Wellcome Trust, the Government Department of Business, Energy and Industrial Strategy"}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2026,3,20]]},"abstract":"<jats:p>\n                    Dengue is spreading globally, and there is urgent need to define immune correlates of protection for this disease. Dengue infection first occurs in the skin following the bite of an infected mosquito; however, knowledge of host immune responses within this site remains sparse. We investigated the phenotypic, functional, and transcriptional profiles of skin and blood T cells in 73 patients with dengue and 10 healthy volunteers. We show that the skin T cell compartment undergoes marked reshaping and is strongly enriched with proliferating CD4\n                    <jats:sup>+<\/jats:sup>\n                    and CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells compared with the blood of patients. Activated skin CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells expressed a core transcriptional signature of tissue-resident memory T (T\n                    <jats:sub>RM<\/jats:sub>\n                    ) cells, supporting their differentiation to the T\n                    <jats:sub>RM<\/jats:sub>\n                    cell lineage during infection. The magnitude of skin and blood CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell responses were associated with protection from hospitalization in this cohort. These data support a protective role of skin-resident and circulating CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells in dengue and warrant evaluation of vaccination strategies inducing skin T\n                    <jats:sub>RM<\/jats:sub>\n                    cells to enhance protective immunity.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.aea7987","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T18:01:06Z","timestamp":1774029666000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":1,"title":["Dengue infection elicits skin tissue-resident and circulating CD8\n                    <sup>+<\/sup>\n                    T cells associated with protection from hospitalization"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0012-0976","authenticated-orcid":true,"given":"Noor Zayanah","family":"Hamis","sequence":"first","affiliation":[{"name":"Emerging Infectious Diseases Programme, Duke-NUS Medical School, Singapore, Singapore."},{"name":"School of Biochemistry and Cellular and Molecular Medicine, University of Bristol, Bristol, UK."},{"name":"Viral Research and Experimental Medicine Centre, SingHealth Duke-NUS Academic Medical Centre, Singapore, Singapore."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4899-8255","authenticated-orcid":true,"given":"Justin SG","family":"Ooi","sequence":"additional","affiliation":[{"name":"Emerging Infectious Diseases Programme, Duke-NUS Medical School, Singapore, Singapore."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ka-Wai","family":"Cheung","sequence":"additional","affiliation":[{"name":"Emerging Infectious Diseases Programme, Duke-NUS Medical School, Singapore, Singapore."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8679-2659","authenticated-orcid":true,"given":"Valerie","family":"Chew","sequence":"additional","affiliation":[{"name":"Emerging Infectious Diseases Programme, Duke-NUS Medical School, Singapore, Singapore."},{"name":"Viral Research and Experimental Medicine Centre, SingHealth Duke-NUS Academic Medical Centre, Singapore, Singapore."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1605-0558","authenticated-orcid":true,"given":"Michaela","family":"Gregorova","sequence":"additional","affiliation":[{"name":"School of Biochemistry and Cellular and Molecular Medicine, University of Bristol, Bristol, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2187-7058","authenticated-orcid":true,"given":"Eugenia Ziying","family":"Ong","sequence":"additional","affiliation":[{"name":"Emerging Infectious Diseases Programme, Duke-NUS Medical School, Singapore, Singapore."},{"name":"Viral Research and Experimental Medicine Centre, SingHealth Duke-NUS Academic Medical Centre, Singapore, Singapore."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2427-671X","authenticated-orcid":true,"given":"Kuan Rong","family":"Chan","sequence":"additional","affiliation":[{"name":"Emerging Infectious Diseases Programme, Duke-NUS Medical School, Singapore, Singapore."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5254-032X","authenticated-orcid":true,"given":"Tun-Linn","family":"Thein","sequence":"additional","affiliation":[{"name":"National Centre for Infectious Diseases, Singapore, Singapore."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4978-5825","authenticated-orcid":true,"given":"Yee-Sin","family":"Leo","sequence":"additional","affiliation":[{"name":"National Centre for Infectious Diseases, Singapore, Singapore."},{"name":"Tan Tock Seng Hospital, Singapore, Singapore."},{"name":"Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore."},{"name":"Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0324-0205","authenticated-orcid":true,"given":"David Chien Boon","family":"Lye","sequence":"additional","affiliation":[{"name":"National Centre for Infectious Diseases, Singapore, Singapore."},{"name":"Tan Tock Seng Hospital, Singapore, Singapore."},{"name":"Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore."},{"name":"Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore."},{"name":"Communicable Diseases Agency, Singapore, Singapore."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0520-1544","authenticated-orcid":true,"given":"Eng Eong","family":"Ooi","sequence":"additional","affiliation":[{"name":"Emerging Infectious Diseases Programme, Duke-NUS Medical School, Singapore, Singapore."},{"name":"Viral Research and Experimental Medicine Centre, SingHealth Duke-NUS Academic Medical Centre, Singapore, Singapore."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6213-9794","authenticated-orcid":true,"given":"Laura","family":"Rivino","sequence":"additional","affiliation":[{"name":"Emerging Infectious Diseases Programme, Duke-NUS Medical School, Singapore, Singapore."},{"name":"School of Biochemistry and Cellular and Molecular Medicine, University of 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