{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T12:22:01Z","timestamp":1792412521616,"version":"4.4.0"},"reference-count":68,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"1","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation NNSF of China","doi-asserted-by":"crossref","award":["21871158"],"award-info":[{"award-number":["21871158"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation NNSF of China","doi-asserted-by":"crossref","award":["22071129"],"award-info":[{"award-number":["22071129"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2026,1,2]]},"abstract":"<jats:p>\n                    Recently, fluoroalkyl-substituted bicyclo[1.1.1]pentanes (BCPs) have attracted considerable attention from the medicinal chemistry community due to their superior physicochemical properties as pharmaceutical bioisosteres of benzene rings. However, related early medicinal research is hampered by a number of challenges, including insufficient and lengthy construction of valuable fluoroalkyl BCP building blocks. Here, we report a general approach to fluoroalkyl-substituted BCP-BPins in a single step using [1.1.1]propellane and economical B\n                    <jats:sub>2<\/jats:sub>\n                    Pin\n                    <jats:sub>2<\/jats:sub>\n                    in which fluoroalkylhalides serve as radical precursors in conjunction with C\u2500C\/C\u2500B couplings featuring mild conditions, easy setup, and broad scope. The diverse transformation of active boryl is applicable to the synthesis of valuable fluorinated bicyclic building blocks, including a commercial drug analog. Detailed mechanism and kinetic studies suggest that the key to the excellent three-component coupling selectivity of the reaction is the different tendencies of BCP-nickel and fluoroalkyl-nickel species to undergo C\u2500Ni bond cleavage or reductive elimination.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.aea8588","type":"journal-article","created":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T18:59:44Z","timestamp":1767380384000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":4,"title":["Nickel-catalyzed radical relay enabled chemoselective fluoroalkyl-borylation of [1.1.1]propellane under kinetic control"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2091-7679","authenticated-orcid":true,"given":"Yaxing","family":"Wu","sequence":"first","affiliation":[{"name":"Key Laboratory of Bioorganic Phosphorus Chemistry &amp; Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Haidian District, Beijing 100084, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuling","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Systems Bioengineering, Ministry of Education, Department of Pharmaceutical Engineering, School of Chemical Engineering and Technology, Tianjin University, Jingnan District, Tianjin 300350, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingqi","family":"Han","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bioorganic Phosphorus Chemistry &amp; Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Haidian District, Beijing 100084, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7562-4942","authenticated-orcid":true,"given":"Xiangyu","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bioorganic Phosphorus Chemistry &amp; Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Haidian District, Beijing 100084, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9804-9336","authenticated-orcid":true,"given":"Ruitong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bioorganic Phosphorus Chemistry &amp; Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Haidian District, Beijing 100084, P. R. 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