{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T18:43:45Z","timestamp":1776883425081,"version":"3.51.2"},"reference-count":118,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"17","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1S10OD030432"],"award-info":[{"award-number":["1S10OD030432"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA054174"],"award-info":[{"award-number":["CA054174"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG080037"],"award-info":[{"award-number":["R01AG080037"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30CA054174"],"award-info":[{"award-number":["P30CA054174"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["S10OD021805-01"],"award-info":[{"award-number":["S10OD021805-01"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS112263"],"award-info":[{"award-number":["R01NS112263"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004917","name":"Cancer Prevention and Research Institute of Texas","doi-asserted-by":"publisher","award":["RP220470"],"award-info":[{"award-number":["RP220470"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004917","name":"Cancer Prevention and Research Institute of Texas","doi-asserted-by":"publisher","award":["RP220662"],"award-info":[{"award-number":["RP220662"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004917","name":"Cancer Prevention and Research Institute of Texas","doi-asserted-by":"publisher","award":["RP210126"],"award-info":[{"award-number":["RP210126"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]},{"name":"UT Health San Antonio"},{"name":"Office of the Vice President for Research at UT Health San Antonio"},{"name":"The William and Ella Owens Medical Research Foundation"},{"name":"The Peter Bradley Carlson Charitable Trust"},{"name":"ThriveWell Cancer Foundation"}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2026,4,24]]},"abstract":"<jats:p>\n                    The major barrier to clinical translation of \u03b1CD137 immunotherapy is separating antitumor efficacy from hepatotoxicity driven by IFN-\u03b3\u2013producing CD8 T cells. We propose a strategy to limit toxicity by promoting contraction of excessively expanded CD8 T cells. We identify CD11c\n                    <jats:sup>+<\/jats:sup>\n                    KLRG1\n                    <jats:sup>+<\/jats:sup>\n                    effector CD8 T cells (CD11c\n                    <jats:sup>+<\/jats:sup>\n                    T\n                    <jats:sub>E<\/jats:sub>\n                    ) as the primary source of IFN-\u03b3, recirculating between blood and secondary lymphoid organs (SLOs), where they undergo apoptosis during contraction. We show that lymphotoxin \u03b2 receptor (LT\u03b2R) signaling restrains this contraction. Mechanistically, lymphotoxin-expressing B cells activate LT\u03b2R in fibroblastic reticular cells (FRCs), suppressing apoptosis of CD11c\n                    <jats:sup>+<\/jats:sup>\n                    T\n                    <jats:sub>E<\/jats:sub>\n                    cells in the spleen and sustaining their systemic circulation and liver infiltration. Pharmacological LT\u03b2R blockade abrogates hepatotoxicity by reducing the accumulation of IFN-\u03b3\u2013producing CD11c\n                    <jats:sup>+<\/jats:sup>\n                    T\n                    <jats:sub>E<\/jats:sub>\n                    cells while preserving tumor-specific CD8 T cell responses. These findings identify LT\u03b2R as a key regulator of effector CD8 T cell persistence and support the use of LT\u03b2R antagonists to improve the safety of \u03b1CD137-based immunotherapy.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.aea8737","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T17:59:52Z","timestamp":1776880792000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Selective elimination of circulating effector CD8 T cells via LT\u03b2R blockade separates anti-CD137 efficacy from toxicity"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0258-425X","authenticated-orcid":true,"given":"Sergey A.","family":"Shein","sequence":"first","affiliation":[{"name":"Department of Microbiology, Immunology, and Molecular Genetics, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6177-2379","authenticated-orcid":true,"given":"Anna A.","family":"Korchagina","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Molecular Genetics, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5385-459X","authenticated-orcid":true,"given":"Li-Ju","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, UTHSCSA, San Antonio, TX, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhao","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, UTHSCSA, San Antonio, TX, USA."},{"name":"Greehey Children\u2019s Cancer Research Institute, San Antonio, TX, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6806-2185","authenticated-orcid":true,"given":"Yidong","family":"Chen","sequence":"additional","affiliation":[{"name":"Greehey Children\u2019s Cancer Research Institute, San Antonio, TX, USA."},{"name":"Department of Population Health Sciences, UTHSCSA, San Antonio, TX, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6805-3725","authenticated-orcid":true,"given":"Jacob S.","family":"Fisher","sequence":"additional","affiliation":[{"name":"Department of Immunology, Mayo Clinic, Phoenix, AZ, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7685-573X","authenticated-orcid":true,"given":"Burkhard","family":"Ludewig","sequence":"additional","affiliation":[{"name":"Institute of Immunobiology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0398-9988","authenticated-orcid":true,"given":"Jessica N.","family":"Lancaster","sequence":"additional","affiliation":[{"name":"Department of Immunology, Mayo Clinic, Phoenix, AZ, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8441-6617","authenticated-orcid":true,"given":"Yang-Xin","family":"Fu","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Tsinghua University, Beijing, China."},{"name":"Changping Laboratory, Beijing, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1857-9199","authenticated-orcid":true,"given":"Ekaterina","family":"Koroleva","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Molecular Genetics, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6042-0152","authenticated-orcid":true,"given":"Alexei V.","family":"Tumanov","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Molecular Genetics, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.3.1313"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-22-1029"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.968360"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2022.10.001"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-21-2918"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.186.1.47"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20121190"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-10-043463"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-06-2184"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2023.06.007"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0697-682"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2015.00117"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13102288"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-16-1272"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-06-741041"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-19-0608"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.133647"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-10088-1"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.09.014"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2025930118"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-26645-6"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1080\/19420862.2023.2167189"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-16-0194"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-17-1847"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2017.1296996"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2021.100464"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.202048762"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.7.4194"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-010-0846-9"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1000927"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.06.037"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2024.111569"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2023-007364"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-14-0118"},{"key":"e_1_3_2_36_2","first-page":"3459","article-title":"Anti-4-1BB monoclonal antibody enhances rejection of large tumor burden by promoting survival but not clonal expansion of tumor-specific CD8+ T cells","volume":"62","author":"May K. F.","year":"2002","unstructured":"K. F. May Jr., L. Chen, P. Zheng, Y. Liu, Anti-4-1BB monoclonal antibody enhances rejection of large tumor burden by promoting survival but not clonal expansion of tumor-specific CD8+ T cells. Cancer Res. 62, 3459\u20133465 (2002).","journal-title":"Cancer Res."},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.9.4796"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0213604"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/73136"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1501053"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/70938"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.03.012"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1014188108"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1999.9811"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200626255"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8171323"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.23.021704.115719"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2832"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2018.08.003"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80588-9"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.712632"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.adq8796"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200839057"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1016-8478(23)10765-5"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-1056"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20132687"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4400374"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.10.5079"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.02.011"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2014.78"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.159.7.3288"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.19.14307"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(02)00397-7"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.202149263"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2588"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-15-0510"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.154.11.5684"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2006.01.004"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200324087"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-016-0416-x"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.138.10.3130"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1805542115"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-2498(01)00319-9"},{"key":"e_1_3_2_74_2","first-page":"S86","article-title":"CD11c is upregulated in CD8+ T cells of patients with Behcet\u2019s disease","volume":"34","author":"Park Y. J.","year":"2016","unstructured":"Y. J. Park, M. J. Park, S. Park, E. S. Lee, CD11c is upregulated in CD8+ T cells of patients with Behcet\u2019s disease. Clin. Exp. Rheumatol. 34, S86\u2013S91 (2016).","journal-title":"Clin. Exp. Rheumatol."},{"key":"e_1_3_2_75_2","first-page":"419","article-title":"Role of new population of peripheral CD11c(+)CD8(+) T cells and CD4(+)CD25(+) regulatory T cells during acute and remission stages in rheumatoid arthritis patients","volume":"40","author":"Kao J. K.","year":"2007","unstructured":"J. K. Kao, Y. T. Hsue, C. Y. Lin, Role of new population of peripheral CD11c(+)CD8(+) T cells and CD4(+)CD25(+) regulatory T cells during acute and remission stages in rheumatoid arthritis patients. J. Microbiol. Immunol. Infect. 40, 419\u2013427 (2007).","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0528.2002.017412.x"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI174984"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(03)00116-X"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01223-14"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2012.10.015"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00568"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.837370"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.11.002"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-021-00878-5"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3846"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-023-00857-x"},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1001345"},{"key":"e_1_3_2_88_2","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12979"},{"key":"e_1_3_2_89_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20221220"},{"key":"e_1_3_2_90_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abj0641"},{"key":"e_1_3_2_91_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-020-00533-3"},{"key":"e_1_3_2_92_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2016.08.018"},{"key":"e_1_3_2_93_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2014.02.002"},{"key":"e_1_3_2_94_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.11.7217"},{"key":"e_1_3_2_95_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2580"},{"key":"e_1_3_2_96_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-03459-5"},{"key":"e_1_3_2_97_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI40040"},{"key":"e_1_3_2_98_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.189.2.403"},{"key":"e_1_3_2_99_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09728-3"},{"key":"e_1_3_2_100_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-14293-1"},{"key":"e_1_3_2_101_2","first-page":"129","article-title":"Systematic analysis of the prognostic value and immunological function of LTBR in human cancer","volume":"16","author":"Wu Y.","year":"2024","unstructured":"Y. Wu, S. Zhao, W. Guo, Y. Liu, M. D. M. Requena Mullor, R. A. Rodriguez, R. Wei, Systematic analysis of the prognostic value and immunological function of LTBR in human cancer. Aging 16, 129\u2013152 (2024).","journal-title":"Aging"},{"key":"e_1_3_2_102_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-024-01478-9"},{"key":"e_1_3_2_103_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21317-x"},{"key":"e_1_3_2_104_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2009.08.021"},{"key":"e_1_3_2_105_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-308810"},{"key":"e_1_3_2_106_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2014.09.003"},{"key":"e_1_3_2_107_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-0217"},{"key":"e_1_3_2_108_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-08426-5"},{"key":"e_1_3_2_109_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-024-00728-0"},{"key":"e_1_3_2_110_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2024.105154"},{"key":"e_1_3_2_111_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1369626"},{"key":"e_1_3_2_112_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2022.01.002"},{"key":"e_1_3_2_113_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-23-2716"},{"key":"e_1_3_2_114_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-54874-y"},{"key":"e_1_3_2_115_2","doi-asserted-by":"publisher","DOI":"10.1002\/imt2.233"},{"key":"e_1_3_2_116_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.17.9302"},{"key":"e_1_3_2_117_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20020215"},{"key":"e_1_3_2_118_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80589-0"},{"key":"e_1_3_2_119_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2014.006"}],"container-title":["Science Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciadv.aea8737","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T17:59:58Z","timestamp":1776880798000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciadv.aea8737"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,24]]},"references-count":118,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2026,4,24]]}},"alternative-id":["10.1126\/sciadv.aea8737"],"URL":"https:\/\/doi.org\/10.1126\/sciadv.aea8737","relation":{},"ISSN":["2375-2548"],"issn-type":[{"value":"2375-2548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,24]]},"assertion":[{"value":"2025-07-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eaea8737"}}