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Adv."],"published-print":{"date-parts":[[2026,3,6]]},"abstract":"<jats:p>High-fidelity fast excitatory neurotransmission in the mammalian central nervous system is conducted by the AMPA receptor (AMPAR) subfamily of ionotropic glutamate receptors. AMPARs exist as complexes of the pore-lining \u03b1 subunits GluA1\u20134 and a number of auxiliary subunits shaping their functional properties. The first discovered family of auxiliary subunits comprises the transmembrane AMPAR regulatory proteins (TARPs). Together with germ cell\u2013specific gene 1\u2013like (GSG1L), they belong to the PMP-22\/EMP\/MP20\/claudin superfamily sharing substantial sequence homology and a 4-transmembrane domain (4-TMD) topology. Here, we identify the claudin Cldn24 as a novel AMPAR auxiliary subunit in cerebellar granule cells (CGCs). Specifically accelerating the recovery of desensitized receptors, Cldn24 counterbalances gating modulation of GluA by TARP-\u03b32 and GSG1L in CGCs and hence enables fast reactivation of native receptors. These features substantially expand the tuning properties of hitherto known AMPAR auxiliary subunits and render Cldn24 a powerful enhancer of AMPAR fidelity.<\/jats:p>","DOI":"10.1126\/sciadv.aeb0196","type":"journal-article","created":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T18:58:34Z","timestamp":1772823514000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":2,"title":["Claudin 24\u2014A novel enhancer of AMPA receptor fidelity"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4512-3477","authenticated-orcid":true,"given":"Tobias","family":"Strasdeit","sequence":"first","affiliation":[{"name":"Institute of Neuro- and Sensory Physiology, Medical Faculty, Heinrich Heine University, University Hospital D\u00fcsseldorf, 40225 D\u00fcsseldorf, Germany."},{"name":"Department of Biochemistry I\u2014Receptor Biochemistry, Ruhr University Bochum, 44780 Bochum, 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