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Adv."],"published-print":{"date-parts":[[2026,2,27]]},"abstract":"<jats:p>\n                    Iron deficiency, anemia, and\n                    <jats:italic toggle=\"yes\">Plasmodium<\/jats:italic>\n                    infection are global health challenges with overlapping geographical distributions, particularly affecting pregnant women in Africa, yet the mechanisms underlying their interactions remain poorly understood. We used a multilayered approach combining clinical data from Malawian pregnant women (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u00a0=\u00a0711) in the REVAMP trial, a genetic mouse model [\n                    <jats:italic toggle=\"yes\">Tmprss6<\/jats:italic>\n                    -knockout (KO)], and in vitro\n                    <jats:italic toggle=\"yes\">Plasmodium falciparum<\/jats:italic>\n                    cultures to clarify iron-malaria associations. Iron deficiency was associated with 50% reduced\n                    <jats:italic toggle=\"yes\">P. falciparum<\/jats:italic>\n                    parasitemia in pregnant women [95% CI (30 to 64%),\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u00a0&lt;\u00a00.0001], while iron-deficient mice exhibited improved survival against\n                    <jats:italic toggle=\"yes\">P. berghei<\/jats:italic>\n                    (median 15.5 days versus 7.0 days for WT mice) and protection from cerebral malaria (83% versus 17% survival). Iron chelation substantially changed the transcriptomic and proteomic profile of cultured\n                    <jats:italic toggle=\"yes\">P. falciparum<\/jats:italic>\n                    parasites. Intravenous iron supplementation did not increase parasitemia when coupled with malaria prevention. These findings demonstrate that iron deficiency protects against\n                    <jats:italic toggle=\"yes\">Plasmodium<\/jats:italic>\n                    infection and support World Health Organization recommendations for iron supplementation in malaria-endemic regions when combined with adequate malaria prevention strategies in place.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.aeb0828","type":"journal-article","created":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T18:58:20Z","timestamp":1772218700000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":1,"title":["Host iron deficiency protects against\n                    <i>Plasmodium<\/i>\n                    infection and drives parasite molecular 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