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Adv."],"published-print":{"date-parts":[[2026,10,9]]},"abstract":"<jats:p>\n                    Clusters of nanoparticles enable electric and magnetic resonances and strong light\u2013molecule interactions, including plasmonic resonance energy transfer (PRET). The optical nanocircuit concept provides a predictive RLC framework for these responses, but experimental realization has been limited by insufficient control over nanogaps and molecular placement. Here, we introduce a molecularly addressable optical nanocircuit based on a robust three-dimensional (3D) DNA origami. We demonstrate that gold nanoparticles and dye-loaded origami function as distinct circuit elements, with the latter acting as a resistor-coupled capacitor that directly participates in resonance. This capability enables deterministic assembly of nanocircuits with controlled symmetry and tunable nanogaps. The multilayer barrel scaffold yields a non\u2013close-packed, symmetry-broken trimer with a magnetic resonance exhibiting a\n                    <jats:italic toggle=\"yes\">Q<\/jats:italic>\n                    -factor of \u223c19.2, exceeding values reported for comparable plasmonic clusters. Selective dye loading onto origami enables predictive light\u2013molecule coupling, producing a 100-fold PRET enhancement in dimers over monomers. This approach provides a versatile route to designer optical resonances for nanophotonic applications.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.aeb2001","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:58:33Z","timestamp":1791395913000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":0,"title":["3D DNA origami-enabled molecularly addressable optical nanocircuit"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1825-9163","authenticated-orcid":true,"given":"Jaewon","family":"Lee","sequence":"first","affiliation":[{"name":"KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul 02841, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3585-3963","authenticated-orcid":true,"given":"Hayun","family":"Ahn","sequence":"additional","affiliation":[{"name":"KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul 02841, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2964-3362","authenticated-orcid":true,"given":"Kyung Hun","family":"Rho","sequence":"additional","affiliation":[{"name":"KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul 02841, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5658-3546","authenticated-orcid":true,"given":"Shelley F. J.","family":"Wickham","sequence":"additional","affiliation":[{"name":"School of Chemistry, School of Physics, The University of Sydney Nano Institute, The University of Sydney, Sydney, NSW 2006, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1395-9267","authenticated-orcid":true,"given":"William M.","family":"Shih","sequence":"additional","affiliation":[{"name":"Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts 02115, United States."},{"name":"Department of Cancer Biology, Dana-Farber Cancer Institute; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02215, United States."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6659-3457","authenticated-orcid":true,"given":"Seungwoo","family":"Lee","sequence":"additional","affiliation":[{"name":"KU-KIST Graduate School of Converging 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