{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:02:00Z","timestamp":1789585320792,"version":"build-2803163510"},"reference-count":94,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"38","funder":[{"DOI":"10.13039\/501100001717","name":"Leiden University","doi-asserted-by":"publisher","award":["Fellowship"],"award-info":[{"award-number":["Fellowship"]}],"id":[{"id":"10.13039\/501100001717","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["OCENW.M.21.057"],"award-info":[{"award-number":["OCENW.M.21.057"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"name":"S\u00e3o Paulo Foundation Research","award":["2018\/00719-9"],"award-info":[{"award-number":["2018\/00719-9"]}]},{"name":"S\u00e3o Paulo Foundation Research","award":["2014\/26437-9"],"award-info":[{"award-number":["2014\/26437-9"]}]}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2026,9,18]]},"abstract":"<jats:p>\n                    Intestinal dendritic cells (DCs) play a central role in maintaining gut tolerance through priming of peripheral regulatory T cells (pT\n                    <jats:sub>reg<\/jats:sub>\n                    cells). DC tolerogenicity has been linked to catabolic metabolism, but the role of AMP-activated kinase (AMPK), a key regulator of catabolic metabolism, in regulating intestinal tolerance remains unclear. We found high AMPK activation in intestinal DCs, and loss of AMPK\u03b11 in CD11c-expressing cells (CD11c\n                    <jats:sup>\u0394AMPK\u03b11<\/jats:sup>\n                    ) led to reduced frequencies of intestinal RALDH\n                    <jats:sup>+<\/jats:sup>\n                    CD103\n                    <jats:sup>+<\/jats:sup>\n                    cDC2s. This was associated with reduced pT\n                    <jats:sub>reg<\/jats:sub>\n                    cell induction and consequently increased type 2 immunity in models of intestinal helminth infection. Correspondingly, CD103\n                    <jats:sup>+<\/jats:sup>\n                    cDC2s from helminth-infected CD11c\n                    <jats:sup>\u0394AMPK\u03b11<\/jats:sup>\n                    mice failed to prime T\n                    <jats:sub>reg<\/jats:sub>\n                    cells ex vivo. Similarly, T\n                    <jats:sub>reg<\/jats:sub>\n                    cell induction by AMPK-deficient human retinoic acid (RA)\u2013induced tolerogenic CD103\n                    <jats:sup>+<\/jats:sup>\n                    DCs was compromised. Mechanistically, AMPK underpinned RA-driven tolerogenicity by promoting RALDH activity and TGF-\u03b2 secretion in a FoxO3-dependent manner, independent from metabolic reprogramming. Our findings identify AMPK as a key regulator of intestinal DC-mediated tolerance and as a therapeutic target to counter intestinal inflammatory disease.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.aeb4813","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T18:02:56Z","timestamp":1789581776000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Metabolic sensor AMPK licenses intestinal CD103\n                    <sup>+<\/sup>\n                    DCs to induce T\n                    <sub>reg<\/sub>\n                    responses"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9333-869X","authenticated-orcid":true,"given":"Thiago A.","family":"Patente","sequence":"first","affiliation":[{"name":"Leiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1811-2465","authenticated-orcid":true,"given":"Julian","family":"van Duijvenvoorde","sequence":"additional","affiliation":[{"name":"Leiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9864-7272","authenticated-orcid":true,"given":"Graham A.","family":"Heieis","sequence":"additional","affiliation":[{"name":"Leiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4475-5854","authenticated-orcid":true,"given":"Eline C.","family":"Brombacher","sequence":"additional","affiliation":[{"name":"Leiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8422-6810","authenticated-orcid":true,"given":"Leonard R.","family":"Pelgrom","sequence":"additional","affiliation":[{"name":"Leiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4853-5843","authenticated-orcid":true,"given":"Joost","family":"Lambooij","sequence":"additional","affiliation":[{"name":"Leiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6990-9165","authenticated-orcid":true,"given":"Anna","family":"Zawistowska-Deniziak","sequence":"additional","affiliation":[{"name":"Leiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands."},{"name":"Pathogen Immunobiology Group, Institute of Experimental Zoology, Faculty of Biology, University of Warsaw, 02-96 Warsaw, Poland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2085-7872","authenticated-orcid":true,"given":"Martina","family":"Erb\u00ec","sequence":"additional","affiliation":[{"name":"Leiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Otto","sequence":"additional","affiliation":[{"name":"Leiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0613-8372","authenticated-orcid":true,"given":"Arifa","family":"Ozir-Fazalalikhan","sequence":"additional","affiliation":[{"name":"Leiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Barnhoorn","sequence":"additional","affiliation":[{"name":"Leiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7552-0076","authenticated-orcid":true,"given":"Jos\u00e9 J.","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Leiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"van der Reijden","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4532-9120","authenticated-orcid":true,"given":"Alwin J.","family":"van der Ham","sequence":"additional","affiliation":[{"name":"Leiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2274-9325","authenticated-orcid":true,"given":"Lukas J. A. C.","family":"Hawinkels","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8856-5799","authenticated-orcid":true,"given":"Bruno A.","family":"Guigas","sequence":"additional","affiliation":[{"name":"Leiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9526-6781","authenticated-orcid":true,"given":"Jos\u00e9 A. M.","family":"Barbuto","sequence":"additional","affiliation":[{"name":"Laboratory of Tumor Immunology, Department of Immunology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rick M.","family":"Maizels","sequence":"additional","affiliation":[{"name":"School of Infection and Immunity, University of Glasgow, 120 University Place, G12 8TA Glasgow, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3764-5131","authenticated-orcid":true,"given":"Bart","family":"Everts","sequence":"additional","affiliation":[{"name":"Leiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.75.10.5132"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.12.004"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.191.3.411"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.175166"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2009.13"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20070590"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1145697"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20070602"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-021-00448-w"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-025-08982-4"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2025.03.020"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-025-09173-x"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2014.64"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20151159"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3771"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2019.02.003"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2833"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-03-419747"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04804-6"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1303316"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-71029-5_10"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2020.01.015"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-022-00547-x"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.01.013"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2018.11.011"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.202401024"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1502218"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0313157"},{"key":"e_1_3_2_30_2","doi-asserted-by":"crossref","unstructured":"G. A. Heieis T. A. Patente T. Tak L. Almeida B. Everts Spectral flow cytometry reveals metabolic heterogeneity in tissue macrophages. bioRxiv 493548 [Preprint] (2022); https:\/\/doi.org\/10.1101\/2022.05.26.493548.","DOI":"10.1101\/2022.05.26.493548"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111032"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.12-204024"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2020.11.007"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-09-245274"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.6.3504"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0804048"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.4556"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abd3774"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0705070104"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1152\/advan.00052.2006"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.02.103"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells8091110"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.08.034"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gpb.2020.01.001"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M705325200"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80595-4"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0910341107"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200636751"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2015.73"},{"key":"e_1_3_2_50_2","doi-asserted-by":"crossref","unstructured":"A. Andrusaite O. Ridgewell A. Ahlback H. Webster H. Yamaguchi M. Peel A. Frede S. Al-Khalidi A. Farthing A. Heawood A. Smith E. Roberts A. Mowat R. Maizels G. Perona-Wright S. Milling Intestinal helminth skews DC2 development towards regulatory phenotype to counter the anti-helminth immune response. bioRxiv 612410 [Preprint] (2024); https:\/\/doi.org\/10.1101\/2024.09.11.612410.","DOI":"10.1101\/2024.09.11.612410"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05089-y"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05309-5"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05141-x"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1020056"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001269"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.3347\/kjp.2012.50.1.29"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1601"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2017.95"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2017.05.032"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-041015-055427"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-011-0748-0"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-53112-9"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1729"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2012.49"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1002\/ctd2.70043"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr400161b"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2011.01015.x"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25095054"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2024.109589"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M804469200"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1111\/cas.12633"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00485"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M107895200"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.03.176"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.3945\/jn.113.179549"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1001672"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3408"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1125-3"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002701"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.ado5088"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.54792"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2417308122"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.08.012"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature13577"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI57456"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1400374"},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.08.029"},{"key":"e_1_3_2_88_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.08.028"},{"key":"e_1_3_2_89_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004684"},{"key":"e_1_3_2_90_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20062648"},{"key":"e_1_3_2_91_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09571"},{"key":"e_1_3_2_92_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac201267k"},{"key":"e_1_3_2_93_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-018-0308-4"},{"key":"e_1_3_2_94_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-3606-9_7"},{"key":"e_1_3_2_95_2","first-page":"229","article-title":"AMPK: Methods and protocols","volume":"1732","author":"Garc\u00eda-Tard\u00f3n N.","year":"2018","unstructured":"N. Garc\u00eda-Tard\u00f3n, B. Guigas, AMPK: Methods and protocols. Methods Mol. Biol. 1732, 229\u2013237 (2018).","journal-title":"Methods Mol. Biol."}],"container-title":["Science Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciadv.aeb4813","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T18:03:21Z","timestamp":1789581801000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciadv.aeb4813"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,18]]},"references-count":94,"journal-issue":{"issue":"38","published-print":{"date-parts":[[2026,9,18]]}},"alternative-id":["10.1126\/sciadv.aeb4813"],"URL":"https:\/\/doi.org\/10.1126\/sciadv.aeb4813","relation":{},"ISSN":["2375-2548"],"issn-type":[{"value":"2375-2548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,18]]},"assertion":[{"value":"2025-08-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eaeb4813"}}