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Adv."],"published-print":{"date-parts":[[2026,9,4]]},"abstract":"<jats:p>\n                    Many species display mating-related sleep suppression to maximize reproductive success, yet the underlying neural mechanisms in mammals remain unclear. Here, we report that male mice exhibit delayed sleep onset and reduced sleep duration in periods following successful mating, while females are unaffected. Single-cell transcriptomics identifies a group of sleep-promoting Rxfp1-expressing neurons in the preoptic area of hypothalamus (POA\n                    <jats:sup>Rxfp1<\/jats:sup>\n                    neurons), and fiber photometry reveals selective inhibition of them during and after mating in male mice. Lifting this inhibition via chemogenetic activation reverses sleep suppression in mated males. Monosynaptic retrograde tracing from these POA\n                    <jats:sup>Rxfp1<\/jats:sup>\n                    neurons identifies male-biased \u03b3-aminobutyric acid\u2013releasing inputs from the principal nucleus of the bed nucleus of the stria terminalis (BNSTpr). Notably, optogenetic activation of these neurons induces immediate wakefulness specifically in male mice, and BNSTpr \u2192 POA\n                    <jats:sup>Rxfp1<\/jats:sup>\n                    neurons are hyperactive after mating. Together, these findings establish a BNSTpr \u2192 POA\n                    <jats:sup>Rxfp1<\/jats:sup>\n                    circuit that integrates reproductive signals for male-specific sleep suppression in mice.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.aeb6839","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T17:59:26Z","timestamp":1788371966000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":0,"title":["A male-biased hypothalamic circuit modulates postmating sleep suppression in mice"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9471-1271","authenticated-orcid":true,"given":"Jin","family":"Zhao","sequence":"first","affiliation":[{"name":"Institute of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China."},{"name":"University of Chinese Academy of 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