{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T18:55:51Z","timestamp":1781290551108,"version":"3.54.1"},"reference-count":46,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"24","funder":[{"name":"National Institute of Health","award":["R01 AI151167"],"award-info":[{"award-number":["R01 AI151167"]}]}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2026,6,12]]},"abstract":"<jats:p>\n                    Lung-resident B cells are increasingly recognized as key contributors to protective immunity against respiratory viruses, yet the mechanisms that govern their generation and specialization remain poorly understood. Here, we identify B cell\u2013intrinsic \u03b1v integrin as a critical negative regulator of germinal center (GC) dynamics and memory B cell formation in the lung following influenza A virus infection. Using B cell\u2013specific \u03b1v knockout mice, we show that loss of B cell \u03b1v integrin leads to persistent GC activity within the inducible bronchus-associated lymphoid tissue and expansion of lung-resident memory B cells, including IgA\n                    <jats:sup>+<\/jats:sup>\n                    and cross-reactive B cells capable of recognizing heterologous influenza variants. Single-cell transcriptomic and B cell receptor sequence analyses reveal that \u03b1v restricts clonal expansion and antigenic diversification of GC and memory B cells in the lung, but not in draining lymph nodes, indicating a spatially restricted mechanism of mucosal B cell regulation. These findings position \u03b1v integrin as a key checkpoint that constrains local mucosal B cell evolution and suggest previously unexplored strategies to improve mucosal vaccine efficacy by enhancing GC activity directly in the lung.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.aeb7633","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T17:58:47Z","timestamp":1781287127000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":0,"title":["B cell \u03b1v integrin regulates tissue specialization and clonal expansion of lung germinal center and memory B cells after viral infection"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-7518-411X","authenticated-orcid":true,"given":"Andrea","family":"Montiel-Armendariz","sequence":"first","affiliation":[{"name":"Center for Immunity and Immunotherapies, Seattle Children\u2019s Research Institute, Seattle, WA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4319-3696","authenticated-orcid":true,"given":"Kelsey","family":"Roe","sequence":"additional","affiliation":[{"name":"Center for Immunity and Immunotherapies, Seattle Children\u2019s Research Institute, Seattle, WA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4270-6813","authenticated-orcid":true,"given":"Jonathan","family":"Lagos","sequence":"additional","affiliation":[{"name":"Center for Immunity and Immunotherapies, Seattle Children\u2019s Research Institute, Seattle, WA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Veronica","family":"Martinez-Castro","sequence":"additional","affiliation":[{"name":"Center for Immunity and Immunotherapies, Seattle Children\u2019s Research Institute, Seattle, WA, 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USA."},{"name":"Department of Immunology, University of Washington, Seattle WA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7078-2560","authenticated-orcid":true,"given":"Mridu","family":"Acharya","sequence":"additional","affiliation":[{"name":"Center for Immunity and Immunotherapies, Seattle Children\u2019s Research Institute, Seattle, WA, USA."},{"name":"Department of Pediatrics, University of Washington, Seattle, WA, 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