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Adv."],"published-print":{"date-parts":[[2026,9,4]]},"abstract":"<jats:p>\n                    Gastropod diversification represents one of the most spectacular evolutionary radiations, underpinned by a fundamentally asymmetric body plan and diverse pigmentation patterns. To understand the genetic underpinnings of these cardinal traits, we constructed a chromosome-level genome assembly for the rainbow abalone,\n                    <jats:italic toggle=\"yes\">Haliotis iris<\/jats:italic>\n                    . Integrating comparative genomics, histoembryology, and molecular assays, we identify a conserved regulatory association between the long non-coding RNA\n                    <jats:italic toggle=\"yes\">lncRNA1<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">pitx<\/jats:italic>\n                    that is associated with asymmetric mantle development. In\n                    <jats:italic toggle=\"yes\">H. iris<\/jats:italic>\n                    , this association is supported by chromatin-contact evidence and exploratory data suggesting a possible miRNA-associated post-transcriptional component. Furthermore, we identify a\n                    <jats:italic toggle=\"yes\">wnt-mitf-tyr<\/jats:italic>\n                    framework for melanogenesis and show that the mantle is the primary site of melanin synthesis. Concurrently, we identify mantle-enriched\n                    <jats:italic toggle=\"yes\">prestin<\/jats:italic>\n                    genes that are vibration-responsive, consistent with a possible sensory specialization of the mantle. These findings provide molecular insight into asymmetry, pigmentation, and mantle multifunctionality in gastropods.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.aeb8392","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T17:58:46Z","timestamp":1788544726000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Abalone genomics reveals an ancient asymmetry axis and the multifunctionality of the mantle"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5007-664X","authenticated-orcid":true,"given":"Xiaotong","family":"Wang","sequence":"first","affiliation":[{"name":"School of Fisheries, Ludong University, Yantai, 264025, China."},{"name":"Shaanxi Key Laboratory of Qinling Ecological Intelligent Monitoring and Protection, School of Life Science and Technology, Northwestern Polytechnical University, Xi\u2019an, 710072, China."},{"name":"Yantai Institute, China Agricultural University, Yantai, 264670, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2364-5725","authenticated-orcid":true,"given":"Chunhui","family":"Li","sequence":"additional","affiliation":[{"name":"Shaanxi Key Laboratory of Qinling Ecological Intelligent Monitoring and Protection, School of Life Science and Technology, Northwestern Polytechnical University, Xi\u2019an, 710072, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3161-5212","authenticated-orcid":true,"given":"Peidong","family":"Xin","sequence":"additional","affiliation":[{"name":"Shaanxi Key Laboratory of Qinling Ecological Intelligent Monitoring and Protection, School of Life Science and Technology, Northwestern Polytechnical University, Xi\u2019an, 710072, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4690-0939","authenticated-orcid":true,"given":"Meiwei","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Fisheries, Ludong University, Yantai, 264025, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2921-5684","authenticated-orcid":true,"given":"Baoyu","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Fisheries, Ludong University, Yantai, 264025, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9597-6660","authenticated-orcid":true,"given":"Tiantian","family":"Chen","sequence":"additional","affiliation":[{"name":"Shaanxi Key Laboratory of Qinling Ecological Intelligent Monitoring and Protection, School of Life Science and Technology, Northwestern Polytechnical University, Xi\u2019an, 710072, 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