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Adv."],"published-print":{"date-parts":[[2026,4,3]]},"abstract":"<jats:p>\n                    The protection of high-value cell lines (assets) relies on physical security by limiting access to samples. We present a cybersecurity-inspired platform that protects biological assets at the genetic level. This technology uses a permutation lock design where an asset can only be decrypted using an authentication code\n                    <jats:italic toggle=\"yes\">r<\/jats:italic>\n                    from a search space composed of\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    objects on a defined keypad. Here, the genetic asset is designed as a scrambled DNA sequence, and the code is a temporal pattern of small molecules that regulate sets of recombinases that can unscramble a DNA sequence into the desired final sequence. In this work, a \u201cblue team\u201d designed and built an encrypted (scrambled) DNA sequence, and a \u201cred team\u201d sought to break the code through an ethical hacking exercise. Two iterations of testing revealed a 0.2% (2 in 990) chance of gaining access to the asset by random search, which is on par with the theoretical goal of 0.1% (1 in 990).\n                  <\/jats:p>","DOI":"10.1126\/sciadv.aeb8556","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T17:58:42Z","timestamp":1775066322000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":1,"title":["Protecting cells at the genetic level and simulating unauthorized access via a biohackathon"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7784-1743","authenticated-orcid":true,"given":"Dowan","family":"Kim","sequence":"first","affiliation":[{"name":"Georgia Institute of Technology, School of Chemical &amp; Biomolecular Engineering, 311 Ferst Drive, Atlanta, GA 30332, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1819-6040","authenticated-orcid":true,"given":"Ishita","family":"Kumar","sequence":"additional","affiliation":[{"name":"Georgia Institute of Technology, School of Chemical &amp; Biomolecular Engineering, 311 Ferst Drive, Atlanta, GA 30332, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed I.","family":"Hassan","sequence":"additional","affiliation":[{"name":"Massachusetts Institute of Technology, Department of Biological Engineering, Synthetic Biology Center, Cambridge, MA 02139, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8320-3828","authenticated-orcid":true,"given":"Luisa F.","family":"Barraza-Vergara","sequence":"additional","affiliation":[{"name":"Georgia Institute of Technology, School of Chemical &amp; Biomolecular Engineering, 311 Ferst Drive, Atlanta, GA 30332, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0844-4776","authenticated-orcid":true,"given":"Christopher A.","family":"Voigt","sequence":"additional","affiliation":[{"name":"Massachusetts Institute of Technology, Department of Biological Engineering, Synthetic Biology Center, Cambridge, MA 02139, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3040-1676","authenticated-orcid":true,"given":"Corey J.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Georgia Institute of Technology, School of Chemical &amp; Biomolecular Engineering, 311 Ferst Drive, Atlanta, GA 30332, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.302.5651.1637"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.303.5665.1743a"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.297.5582.751a"},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/428242b","article-title":"Plague professor gets two years in bioterror case","volume":"428","author":"Check E.","year":"2004","unstructured":"E. 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