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Adv."],"published-print":{"date-parts":[[2026,7,31]]},"abstract":"<jats:p>\n                    Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone that promotes postprandial insulin release and euglycemia. Although GIP is the dominant incretin in humans, the precise mechanisms regulating GIP release from enteroendocrine K cells in vivo remain to be elucidated. Heterotrimeric G proteins of the G\n                    <jats:sub>i<\/jats:sub>\n                    family regulate numerous key physiological functions. To explore the potential role of these proteins in modulating K cell function in vivo, we analyzed mutant mice that allowed us to selectively stimulate G\n                    <jats:sub>i<\/jats:sub>\n                    signaling in K cells or studied mice lacking functional G\n                    <jats:sub>i<\/jats:sub>\n                    in K cells only. 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