{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T18:14:18Z","timestamp":1788545658408,"version":"build-2803163510"},"reference-count":58,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"36","funder":[{"name":"Science Fund for Creative Research Groups of the National Natural Science Foundation of China","award":["82021005"],"award-info":[{"award-number":["82021005"]}]},{"name":"The Major Program of the National Natural Science Foundation of China","award":["82192903"],"award-info":[{"award-number":["82192903"]}]},{"name":"The Major Program of the National Natural Science Foundation of China","award":["81930092"],"award-info":[{"award-number":["81930092"]}]},{"name":"The Chief Scientist Research Project of Hubei Shizhen Laboratory","award":["HSL2024SX0003"],"award-info":[{"award-number":["HSL2024SX0003"]}]}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2026,9,4]]},"abstract":"<jats:p>Pyrethroids are widely used insecticides worldwide, yet their effects on dyslipidemia remain incompletely understood. Our study quantified serum concentrations of seven parent pyrethroids in participants from the Dongfeng-Tongji cohort and evaluated both cross-sectional and prospective associations with lipid levels and dyslipidemia. In cross-sectional analyses, higher serum concentrations of fenvalerate and deltamethrin were consistently associated with increased odds of dyslipidemia and its subtypes, including hypercholesterolemia, hypertriglyceridemia, and hyperbetalipoproteinemia, whereas cyfluthrin was associated with higher odds of hypertriglyceridemia. Prospective analyses revealed that higher baseline serum concentrations of fenvalerate were associated with annual increases in total cholesterol and low-density lipoprotein cholesterol, as well as elevated risk of incident hypertriglyceridemia. Mixture analyses identified fenvalerate as an important contributor in several dyslipidemia subtype models. These findings suggest that pyrethroid exposure, particularly fenvalerate, may contribute to dyslipidemia and highlight the need for further mechanistic investigation and risk evaluation.<\/jats:p>","DOI":"10.1126\/sciadv.aec1001","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T17:58:46Z","timestamp":1788544726000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Associations between pyrethroid insecticide concentrations and dyslipidemia: Findings from the Dongfeng-Tongji cohort"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-6313-3757","authenticated-orcid":true,"given":"Zhen","family":"Yin","sequence":"first","affiliation":[{"name":"Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7269-3888","authenticated-orcid":true,"given":"Yi","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0588-5552","authenticated-orcid":true,"given":"Yutong","family":"You","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guorong","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengyong","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6288-350X","authenticated-orcid":true,"given":"Wenhui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuying","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4915-0853","authenticated-orcid":true,"given":"Shengli","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1755-9578","authenticated-orcid":true,"given":"Tao","family":"Jing","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meian","family":"He","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9931-5106","authenticated-orcid":true,"given":"Tangchun","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4435-7111","authenticated-orcid":true,"given":"Pinpin","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2012.05.007"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2019.6019"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2017.10.115"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2020.106028"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.27573"},{"key":"e_1_3_2_7_2","first-page":"221","article-title":"Chinese guidelines for lipid management (2023)","volume":"51","author":"Wang Z.","year":"2023","unstructured":"Z. Wang, J. Liu, J. Li, N. Wu, G. Lu, Z. Chen, D. Zhao, S. Zhao, R. Gao, Y. Guo, D. Peng, S. Yan, Chinese guidelines for lipid management (2023). Zhonghua Xin Xue Guan Bing Za Zhi 51, 221\u2013255 (2023).","journal-title":"Zhonghua Xin Xue Guan Bing Za Zhi"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)30427-1"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2481"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2008.05.070"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-022-18871-2"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2023.132082"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2023.132637"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.6b05639"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-022-00906-0"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00244-009-9401-0"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2017.07.091"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-013-0023-5"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.0900605"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2019.105264"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-46595-z"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxrep.2023.02.012"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf102567z"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.0901275"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2021.101238"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2014.07.001"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2017.91"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2024.171790"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2010.12.024"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2024.176975"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2025.118686"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.07.059"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-024-01039-5"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-023-01984-4"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2006.08.011"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2019.e02466"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2024.173097"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anireprosci.2017.07.007"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02553-8"},{"key":"e_1_3_2_40_2","first-page":"247","article-title":"Estrogen markedly increases LDL-receptor activity in hypercholesterolemic patients","volume":"31","author":"Inukai T.","year":"2000","unstructured":"T. Inukai, K. Takanashi, K. Takebayashi, K. Tayama, Y. Aso, Y. Takiguchi, Y. Takemura, Estrogen markedly increases LDL-receptor activity in hypercholesterolemic patients. J. Med. 31, 247\u2013261 (2000).","journal-title":"J. Med."},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2018.12.045"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2018.05.086"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2021.149938"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.20745"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/475176a"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13121532"},{"key":"e_1_3_2_47_2","first-page":"e06058","article-title":"Peer review of the pesticide risk assessment of the active substance beta-cyfluthrin","volume":"18","author":"Arena M.","year":"2020","unstructured":"M. Arena, D. Auteri, A. Brancato, L. Bura, L. Carrasco Cabrera, A. Chiusolo, D. Court Marques, F. Crivellente, C. De Lentdecker, M. Egsmose, G. Fait, L. Greco, A. Ippolito, F. Istace, S. Jarrah, D. Kardassi, R. Leuschner, A. Lostia, C. Lythgo, J. O. Magrans, I. Miron, T. Molnar, L. Padovani, J. M. Parra Morte, R. Pedersen, H. Reich, A. Sacchi, M. Santos, R. Serafimova, R. Sharp, A. Stanek, J. Sturma, C. Szentes, A. Terron, A. Theobald, B. Vagenende, L. Villamar-Bouza, Peer review of the pesticide risk assessment of the active substance beta-cyfluthrin. EFSA J. 18, e06058 (2020).","journal-title":"EFSA J."},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2025.109590"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2022.114332"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1509752"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dys053"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2025.109571"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19980115)17:1<101::AID-SIM727>3.0.CO;2-E"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.estlett.1c00285"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2025.126721"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01055015"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2020-102955"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1289\/EHP5838"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13253-014-0180-3"}],"container-title":["Science Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciadv.aec1001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T18:00:45Z","timestamp":1788544845000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciadv.aec1001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,4]]},"references-count":58,"journal-issue":{"issue":"36","published-print":{"date-parts":[[2026,9,4]]}},"alternative-id":["10.1126\/sciadv.aec1001"],"URL":"https:\/\/doi.org\/10.1126\/sciadv.aec1001","relation":{},"ISSN":["2375-2548"],"issn-type":[{"value":"2375-2548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,4]]},"assertion":[{"value":"2025-09-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eaec1001"}}