{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:40:15Z","timestamp":1792608015340,"version":"4.5.0"},"reference-count":66,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"43","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIAID R01Al137078"],"award-info":[{"award-number":["NIAID R01Al137078"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011780","name":"Johns Hopkins Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health","doi-asserted-by":"publisher","award":["Pilot Grant"],"award-info":[{"award-number":["Pilot Grant"]}],"id":[{"id":"10.13039\/100011780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011780","name":"Johns Hopkins Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health","doi-asserted-by":"publisher","award":["Postdoctoral Fellowship"],"award-info":[{"award-number":["Postdoctoral Fellowship"]}],"id":[{"id":"10.13039\/100011780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["Postdoctoral Fellowship"],"award-info":[{"award-number":["Postdoctoral Fellowship"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2026,10,23]]},"abstract":"<jats:p>\n                    The bite of a female mosquito is the critical point of pathogen transmission, yet the fine-scale biting dynamics on human skin remain unknown. Here, we combine high-speed videography, deep-learning\u2013based tracking, and electrophysiology to analyze biting dynamics of the malaria vector\n                    <jats:italic toggle=\"yes\">Anopheles coluzzii<\/jats:italic>\n                    in real time at the human skin interface. We uncover a previously uncharacterized synchronization of mouthpart and leg movements during probing and identify five distinct below skin sub-behaviors: piercing, vessel searching, blood ingestion, retraction, and withdrawal. We show that disruption of the\n                    <jats:italic toggle=\"yes\">orco<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">IR76b<\/jats:italic>\n                    chemosensory genes can alter some components of normal biting but these effects are subtle, suggesting possible plasticity in direct-contact chemosensation and mosquito bite execution. Comparative analyses show genus-specific biting strategies between\n                    <jats:italic toggle=\"yes\">An. coluzzii<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">Aedes aegypti<\/jats:italic>\n                    linked to distinct ways they find blood vessels. Our findings indicate that female mosquitoes exhibit a complex synchronization of body parts at the bite site via motor and chemosensory processes.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.aec2023","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:01:42Z","timestamp":1792605702000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Coordinated mosquito biting dynamics at the human skin interface"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0350-2757","authenticated-orcid":true,"given":"Joanna K.","family":"Konopka","sequence":"first","affiliation":[{"name":"The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA."},{"name":"Johns Hopkins Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danny","family":"Poinapen","sequence":"additional","affiliation":[{"name":"The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA."},{"name":"Robarts Research Institute, Schulich School of Medicine &amp; Dentistry, Western University, London, ON, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5228-8996","authenticated-orcid":true,"given":"Shivam S.","family":"Chitnis","sequence":"additional","affiliation":[{"name":"The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA."},{"name":"HHMI Janelia Research Campus, Ashburn, VA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3187-4269","authenticated-orcid":true,"given":"Carmen M.","family":"Morrow","sequence":"additional","affiliation":[{"name":"HHMI Janelia Research Campus, Ashburn, VA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwyneth M.","family":"Card","sequence":"additional","affiliation":[{"name":"HHMI Janelia Research Campus, Ashburn, VA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5223-8112","authenticated-orcid":true,"given":"Christopher J.","family":"Potter","sequence":"additional","affiliation":[{"name":"The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA."},{"name":"Johns Hopkins Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibmb.2005.02.013"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/bjab021"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.en.36.010191.001035"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2015.06.046"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07848-5"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2025.05.004"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1742758400020816"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2013076117"},{"key":"e_1_3_2_10_2","doi-asserted-by":"crossref","unstructured":"C. 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