{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:09:14Z","timestamp":1792066154865,"version":"4.4.0"},"reference-count":116,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"20","funder":[{"DOI":"10.13039\/501100001656","name":"Helmholtz Association","doi-asserted-by":"publisher","award":["HIL-A03 B"],"award-info":[{"award-number":["HIL-A03 B"]}],"id":[{"id":"10.13039\/501100001656","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["504745852"],"award-info":[{"award-number":["504745852"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["PR1274\/5-1"],"award-info":[{"award-number":["PR1274\/5-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["PR1274\/9-1"],"award-info":[{"award-number":["PR1274\/9-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["PR1274\/13-1"],"award-info":[{"award-number":["PR1274\/13-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01GM1908D"],"award-info":[{"award-number":["01GM1908D"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005224","name":"Deutsches Zentrum f\u00fcr Neurodegenerative Erkrankungen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005224","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005224","name":"Deutsches Zentrum f\u00fcr Neurodegenerative Erkrankungen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005224","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006188","name":"Einstein Stiftung Berlin","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006188","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Deutsche Forschungsgesellschaft","award":["327654276"],"award-info":[{"award-number":["327654276"]}]},{"name":"Deutsche Forschungsgesellschaft","award":["273915538"],"award-info":[{"award-number":["273915538"]}]}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2026,5,15]]},"abstract":"<jats:p>Anti-IgLON5 disease is an autoimmune disease, in which autoantibodies (AABs) against the neuronal cell surface protein IgLON5 lead to profound brain dysfunction and Tau pathology. How \u03b1-IgLON5 AABs cause neuronal Tau protein pathology and neurodegeneration remains unclear. We find that patient-derived \u03b1-IgLON5 AABs cluster IgLON5 proteins with other cell surface proteins, leading to neuronal hyperactivity that triggers pathological Tau missorting and phosphorylation, typically observed early in Tau-related neurodegenerative diseases. In wild-type mice, \u03b1-IgLON5 AABs induce hippocampal Tau phosphorylation and neuroinflammatory responses. Our findings establish a causal link between the \u03b1-IgLON5 AABs and Tau pathology in anti-IgLON5 disease patients and highlight the role of neuronal hyperactivity as a disease-overarching driver of Tau pathology and provide a potential target for therapeutic intervention.<\/jats:p>","DOI":"10.1126\/sciadv.aec2042","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T18:00:56Z","timestamp":1778695256000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":3,"title":["IgLON5 autoimmune antibodies activate Tau via neuronal hyperactivity"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6582-3249","authenticated-orcid":true,"given":"Bilge","family":"Askin","sequence":"first","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany."},{"name":"Einstein Center for Neurosciences (ECN), Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7682-1557","authenticated-orcid":true,"given":"Cagla","family":"Kilic","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9sar","family":"Cordero G\u00f3mez","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany."},{"name":"Department of Neurology and Experimental Neurology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9216-0874","authenticated-orcid":true,"given":"Sophie Lan-Linh","family":"Duong","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany."},{"name":"Department of Neurology and Experimental Neurology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany."},{"name":"Berlin Institute of Health (BIH) at Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvaro","family":"Domingues-Baquero","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Goihl","sequence":"additional","affiliation":[{"name":"Institute of Molecular and Clinical Immunology, Otto-von-Guericke-University, Magdeburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3928-4026","authenticated-orcid":true,"given":"Karsten","family":"Nalbach","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE), Munich, Germany."},{"name":"Munich Cluster for Systems Neurology (SyNergy), Munich, Germany."},{"name":"Neuroproteomics, School of Medicine and Health, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5359-2126","authenticated-orcid":true,"given":"Joana","family":"Petushi","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8751-8185","authenticated-orcid":true,"given":"Pia","family":"Grundsch\u00f6ttel","sequence":"additional","affiliation":[{"name":"Platform for Single Cell Genomics and Epigenomics (PRECISE) at the German Center for Neurodegenerative Diseases and the University of Bonn, Bonn, Germany."},{"name":"Genomics and Immunoregulation, Life and Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany."},{"name":"German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8585-6998","authenticated-orcid":true,"given":"Jessica","family":"Wagner","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE), Munich, Germany."},{"name":"Munich Cluster for Systems Neurology (SyNergy), Munich, Germany."},{"name":"Metabolic Biochemistry, Biomedical Center Munich (BMC), Faculty of Medicine, Ludwig Maximilian University, Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3791-1796","authenticated-orcid":true,"given":"Valentine","family":"Thomas","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janne","family":"Lamberty","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1619-8541","authenticated-orcid":true,"given":"Emily","family":"Withers","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Huber","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Huebschmann","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina","family":"Semenova","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1305-6711","authenticated-orcid":true,"given":"Paul","family":"Turko","sequence":"additional","affiliation":[{"name":"Institute of Integrative Neuroanatomy, Charit\u00e9, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0222-9162","authenticated-orcid":true,"given":"Andrew G.","family":"Newman","sequence":"additional","affiliation":[{"name":"Institute of Cell Biology and Neurobiology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3101-0191","authenticated-orcid":true,"given":"Lisa","family":"Diez","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9704-148X","authenticated-orcid":true,"given":"Marc","family":"Beyer","sequence":"additional","affiliation":[{"name":"Platform for Single Cell Genomics and Epigenomics (PRECISE) at the German Center for Neurodegenerative Diseases and the University of Bonn, Bonn, Germany."},{"name":"German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0336-8284","authenticated-orcid":true,"given":"Elena","family":"De Domenico","sequence":"additional","affiliation":[{"name":"Platform for Single Cell Genomics and Epigenomics (PRECISE) at the German Center for Neurodegenerative Diseases and the University of Bonn, Bonn, Germany."},{"name":"German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1262-6169","authenticated-orcid":true,"given":"Peter","family":"K\u00f6rtvelyessy","sequence":"additional","affiliation":[{"name":"Department of Neurology and Experimental Neurology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany."},{"name":"German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6441-9631","authenticated-orcid":true,"given":"Dirk","family":"Reinhold","sequence":"additional","affiliation":[{"name":"Institute of Molecular and Clinical Immunology, Otto-von-Guericke-University, Magdeburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9540-8700","authenticated-orcid":true,"given":"Anja","family":"Schneider","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1346-8924","authenticated-orcid":true,"given":"Jonas J.","family":"Neher","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE), Munich, Germany."},{"name":"Munich Cluster for Systems Neurology (SyNergy), Munich, Germany."},{"name":"Metabolic Biochemistry, Biomedical Center Munich (BMC), Faculty of Medicine, Ludwig Maximilian University, Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9785-4197","authenticated-orcid":true,"given":"Thomas","family":"Ulas","sequence":"additional","affiliation":[{"name":"Platform for Single Cell Genomics and Epigenomics (PRECISE) at the German Center for Neurodegenerative Diseases and the University of Bonn, Bonn, Germany."},{"name":"Genomics and Immunoregulation, Life and Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany."},{"name":"German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2211-2575","authenticated-orcid":true,"given":"Stefan F.","family":"Lichtenthaler","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE), Munich, Germany."},{"name":"Munich Cluster for Systems Neurology (SyNergy), Munich, Germany."},{"name":"Neuroproteomics, School of Medicine and Health, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1906-0081","authenticated-orcid":true,"given":"Benjamin R.","family":"Rost","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2741-5241","authenticated-orcid":true,"given":"Dietmar","family":"Schmitz","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany."},{"name":"Einstein Center for Neurosciences (ECN), Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany."},{"name":"Institute of Cell Biology and Neurobiology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany."},{"name":"Neuroscience Research Center (NWFZ), Charit\u00e9-Universit\u00e4tsmedizin, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8283-7976","authenticated-orcid":true,"given":"Harald","family":"Pr\u00fcss","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany."},{"name":"Einstein Center for Neurosciences (ECN), Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany."},{"name":"Department of Neurology and Experimental Neurology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5388-2479","authenticated-orcid":true,"given":"Susanne","family":"Wegmann","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany."},{"name":"Einstein Center for Neurosciences (ECN), Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00543-w"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00010.2016"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70051-1"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.800298"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awac090"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.852215"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-016-1591-8"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-024-02805-y"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70090-5"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2004.09.008"},{"key":"e_1_3_2_12_2","unstructured":"Tissue expression of IGLON5 - Summary - The Human Protein Atlas. www.proteinatlas.org\/ENSG00000142549-IGLON5\/tissue."},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2017.00038"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2019.03.004"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2020.07.014"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1151574"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.1600"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2018.00008"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.628438"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-016-0689-1"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25857"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells10040837"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-023-02625-6"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M117.815357"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-025-08548-0"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2014.08.004"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12321"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.5607\/en23025"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2107-13.2013"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24230"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2020.113180"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2006.05226.x"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05440-3"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0304-3"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.01.010"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaw6404"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.633725"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2357-10.2010"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25460"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/88380"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2009.09.027"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2022.577867"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww208"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws092"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awae163"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3506-13.2013"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awae129"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2025.02.019"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.01.033"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0167-10.2010"},{"key":"e_1_3_2_51_2","first-page":"e20210012","article-title":"Encephalitis patient-derived monoclonal GABAA receptor antibodies cause epileptic seizures","volume":"218","author":"Kreye J.","year":"2021","unstructured":"J. Kreye, S. K. Wright, A. van Casteren, L. St\u00f6ffler, M. L. Machule, S. M. Reincke, M. Nikolaus, S. van Hoof, E. Sanchez-Sendin, M. A. Homeyer, C. C. G\u00f3mez, H. C. Kornau, D. Schmitz, A. M. Kaindl, P. Boehm-Sturm, S. Mueller, M. A. Wilson, M. A. Upadhya, D. R. Dhangar, S. Greenhill, G. Woodhall, P. Turko, I. Vida, C. C. Garner, J. Wickel, C. Geis, Y. Fukata, M. Fukata, H. Pr\u00fcss, Encephalitis patient-derived monoclonal GABAA receptor antibodies cause epileptic seizures. J. Exp. Med. 218, e20210012 (2021).","journal-title":"J. Exp. Med."},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.113166"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25666"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-022-02520-z"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells11061024"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2017.05.017"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2019.01.020"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2005.05.001"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0608891104"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1021660531484"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2008.07.015"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-9726.2007.00283.x"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0511065103"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.02.003"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2013.257527"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12325"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-38266-7_7"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3029-15.2016"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.04.045"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.07.039"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww187"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-018-0080-x"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2022.03.034"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2023.11.014"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2013.15"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4328"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/0197-4580(96)00069-3"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-018-1909-9"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-015-0193-3"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.03.005"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1016\/0197-4580(95)00021-6"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(88)91582-X"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2000.7380"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2016.04.005"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.1002\/syn.21965"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.10.014"},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2003.01879.x"},{"key":"e_1_3_2_88_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2022.10.016"},{"key":"e_1_3_2_89_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-025-03457-9"},{"key":"e_1_3_2_90_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2012.06.033"},{"key":"e_1_3_2_91_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15295"},{"key":"e_1_3_2_92_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2006.10.033"},{"key":"e_1_3_2_93_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2414176121"},{"key":"e_1_3_2_94_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.06.036"},{"key":"e_1_3_2_95_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.08-120410"},{"key":"e_1_3_2_96_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2021.102058"},{"key":"e_1_3_2_97_2","first-page":"awag015","article-title":"Brainstem pathology in anti-IgLON5 disease: New insights into early events and tau progression","author":"Reinecke R.","year":"2026","unstructured":"R. Reinecke, S. Nitsch, F. Faber, C. Elmas, M. Gaubinger, A. Simonovska Serra, V. Endmayr, I. Koneczny, E. Berger-Sieczkowski, M. Blaabjerg, M. E. Erro, J. Ferrari, M. Glatzel, A. Heidbreder, B. H\u00f6gl, C. Jansen, J. Lewerenz, P. Moser, L. Myllykangas, J. Krogh Petersen, P. Schnider, A. Stefani, M. J. Titulaer, D. Yilmazer-Hanke, S. Weis, L. Sabater, C. Gaig, E. Gelpi, R. H\u00f6ftberger, Brainstem pathology in anti-IgLON5 disease: New insights into early events and tau progression. Brain, awag015 (2026).","journal-title":"Brain"},{"key":"e_1_3_2_98_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2020.00247"},{"key":"e_1_3_2_99_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-181263"},{"key":"e_1_3_2_100_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004010100423"},{"key":"e_1_3_2_101_2","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000385"},{"key":"e_1_3_2_102_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-018-9042-1"},{"key":"e_1_3_2_103_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts635"},{"key":"e_1_3_2_104_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"e_1_3_2_105_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3885"},{"key":"e_1_3_2_106_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bty895"},{"key":"e_1_3_2_107_2","doi-asserted-by":"crossref","unstructured":"G. Korotkevich V. Sukhov N. Budin B. Shpak M. N. Artyomov A. Sergushichev Fast gene set enrichment analysis. bioRxiv 060012 [Preprint] (2021). https:\/\/doi.org\/10.1101\/060012.","DOI":"10.1101\/060012"},{"key":"e_1_3_2_108_2","doi-asserted-by":"publisher","DOI":"10.1038\/75556"},{"key":"e_1_3_2_109_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cels.2015.12.004"},{"key":"e_1_3_2_110_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506580102"},{"key":"e_1_3_2_111_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2015.01.020"},{"key":"e_1_3_2_112_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1162844"},{"key":"e_1_3_2_113_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-018-0289-8"},{"key":"e_1_3_2_114_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2010.07387.x"},{"key":"e_1_3_2_115_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-018-0082-x"},{"key":"e_1_3_2_116_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-019-0638-x"},{"key":"e_1_3_2_117_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3901"}],"container-title":["Science Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciadv.aec2042","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T18:01:05Z","timestamp":1778695265000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciadv.aec2042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,15]]},"references-count":116,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2026,5,15]]}},"alternative-id":["10.1126\/sciadv.aec2042"],"URL":"https:\/\/doi.org\/10.1126\/sciadv.aec2042","relation":{},"ISSN":["2375-2548"],"issn-type":[{"value":"2375-2548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,15]]},"assertion":[{"value":"2025-09-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eaec2042"}}