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Adv."],"published-print":{"date-parts":[[2026,3,6]]},"abstract":"<jats:p>\n                    Egg production by female schistosomes drives both transmission and pathology of schistosomiasis, affecting over 200 million people. Female maturation relies on the male-derived pheromone \u03b2-alanyl-tryptamine (BATT), but underlying molecular mechanisms are unclear. We identified the BATT-responsive transcription factor gene\n                    <jats:italic toggle=\"yes\">znf362<\/jats:italic>\n                    as a key regulator of female reproductive development. Functional studies showed that\n                    <jats:italic toggle=\"yes\">znf362.1<\/jats:italic>\n                    , but not\n                    <jats:italic toggle=\"yes\">znf362.2<\/jats:italic>\n                    , is essential for BATT-induced ovary and vitellaria maturation. Single-cell transcriptomics and in situ hybridization revealed up-regulation of\n                    <jats:italic toggle=\"yes\">znf362.1<\/jats:italic>\n                    in oocytes and vitellaria S\n                    <jats:sub>1<\/jats:sub>\n                    cells after BATT exposure. Multiomics analysis showed ZNF362.1 directly activates\n                    <jats:italic toggle=\"yes\">Smp_349410<\/jats:italic>\n                    , a female gonad-specific gene encoding a CPEB1 homolog. Loss of\n                    <jats:italic toggle=\"yes\">znf362.1<\/jats:italic>\n                    or\n                    <jats:italic toggle=\"yes\">Smp_349410<\/jats:italic>\n                    impaired oocyte and vitellocyte differentiation without affecting progenitors. Mechanistically,\n                    <jats:italic toggle=\"yes\">Sm<\/jats:italic>\n                    CPEB1 promotes female ovary development by regulating polyadenylation of cyclin B1 mRNA and drives S\n                    <jats:sub>1<\/jats:sub>\n                    cell differentiation in the vitellaria. These findings define a transcriptional and post-transcriptional axis, BATT-\n                    <jats:italic toggle=\"yes\">znf362.1<\/jats:italic>\n                    -\n                    <jats:italic toggle=\"yes\">cpeb1<\/jats:italic>\n                    , that initiates female sexual maturation, offering mechanistic insight into schistosome reproduction and potential targets for schistosomiasis control.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.aec6907","type":"journal-article","created":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T18:58:34Z","timestamp":1772823514000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":1,"title":["A male-pheromone-elevated transcription factor ZNF362.1 in female schistosomes determines sexual maturation"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3557-6435","authenticated-orcid":true,"given":"Mengjie","family":"Gu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Genetics and Development of Complex Phenotypes, Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1867-0726","authenticated-orcid":true,"given":"Wenjun","family":"Cheng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genetics and Development of Complex Phenotypes, Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genetics and 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