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Adv."],"published-print":{"date-parts":[[2026,5,8]]},"abstract":"<jats:p>\n                    Increasing antibiotic-resistant bacterial infections pose a global public health challenge that demands therapeutic strategies beyond conventional antibiotics. The cyclic guanosine monophosphate\u2013adenosine monophosphate synthase stimulator of interferon genes (cGAS-STING) pathway is crucial to innate immune defense through cytosolic DNA detection and antimicrobial response initiation. Emerging evidence suggests that antibiotic-resistant bacteria can subvert or overactivate this pathway, leading to immune evasion and excessive inflammation. Methicillin-resistant\n                    <jats:italic toggle=\"yes\">Staphylococcus aureus<\/jats:italic>\n                    , carbapenem-resistant\n                    <jats:italic toggle=\"yes\">Acinetobacter baumannii<\/jats:italic>\n                    , and multidrug-resistant\n                    <jats:italic toggle=\"yes\">Mycobacterium tuberculosis<\/jats:italic>\n                    exploit cGAS-STING signaling to suppress host immunity or trigger damaging hyperinflammatory responses. This highlights the dual nature of the cGAS-STING pathway in bacterial infections. STING agonists may enhance immune responses against persistent infections, and STING inhibitors can mitigate excessive inflammation caused by resistant pathogens. Targeting the cGAS-STING pathway represents a host-directed therapy that modulates host immunity rather than targeting pathogens. Understanding the interplay between cGAS-STING signaling and antibiotic resistance mechanisms is essential for developing next-generation immunotherapeutics to complement conventional antibacterial treatments.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.aec7001","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T09:53:19Z","timestamp":1778579599000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":3,"title":["Targeting cGAS-STING signaling to overcome antibiotic-resistant bacterial infections: Challenges and opportunities"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1263-8443","authenticated-orcid":true,"given":"Yu Seong","family":"Ham","sequence":"first","affiliation":[{"name":"Department of Molecular and Life Science, Hanyang University, Ansan-si, Gyeonggi-do 15588, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5081-5293","authenticated-orcid":true,"given":"Minseo","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Molecular and Life Science, Hanyang University, Ansan-si, Gyeonggi-do 15588, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4918-961X","authenticated-orcid":true,"given":"Chul-Su","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Molecular and Life Science, Hanyang University, Ansan-si, Gyeonggi-do 15588, South Korea."},{"name":"Department of Molecular Medicine, School of Biopharmaceutical Convergence, Ansan-si, Gyeonggi-do 15588, South Korea."},{"name":"Biopeptics Inc., Ansan-si, Gyeonggi-do 15588, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)02724-0"},{"key":"e_1_3_1_3_2","unstructured":"W. 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