{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T18:35:46Z","timestamp":1787337346331,"version":"build-2736575974"},"reference-count":97,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"34","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01CA266124"],"award-info":[{"award-number":["R01CA266124"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01CA266124"],"award-info":[{"award-number":["R01CA266124"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5R35GM152058"],"award-info":[{"award-number":["5R35GM152058"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"VCU Accelerate Fund"},{"name":"VCU Accelerate Fund"}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2026,8,21]]},"abstract":"<jats:p>\n                    Obesity increases circulating levels of the bioactive sphingolipid metabolite sphingosine-1-phosphate (S1P). Here, we identify adipocyte-expressed sphingosine kinase 2 (SPHK2), an enzyme that produces S1P, as a regulator of adipose tissue browning. Mice with adipocyte-specific deletion of\n                    <jats:italic toggle=\"yes\">Sphk2<\/jats:italic>\n                    were protected from Western diet\u2013induced obesity concomitantly with elevated energy expenditure and browning of subcutaneous fat.\n                    <jats:italic toggle=\"yes\">Sphk2<\/jats:italic>\n                    deletion also enhanced expression of\n                    <jats:italic toggle=\"yes\">Ucp1<\/jats:italic>\n                    and key thermogenic genes, resulting in reduced adiposity and hepatic steatosis, improved glucose tolerance, and insulin sensitivity. Mechanistically, obesogenic diet promoted nuclear localization of SPHK2 in adipocytes, where it cooperated with transcription factors to suppress the thermogenic transcriptome. Adipocyte SPHK2 contributes to homeostatic circulating S1P levels and drive the pathogenic rise of S1P in response to obesogenic diet. Our findings reveal a distinct role of adipocyte SPHK2 in regulation of the thermogenic program important for whole-body metabolic homeostasis and energy expenditure, highlighting SPHK2 as a potential therapeutic target for treatment of metabolic disorders.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.aec7066","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T17:58:41Z","timestamp":1787335121000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Sphingosine kinase 2 regulates adipocyte browning and whole-body metabolism"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2880-0301","authenticated-orcid":true,"given":"Ryan D. R.","family":"Brown","sequence":"first","affiliation":[{"name":"Department of Cellular, Molecular and Genetic Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3132-4203","authenticated-orcid":true,"given":"Cynthia","family":"Weigel","sequence":"additional","affiliation":[{"name":"Department of Cellular, Molecular and Genetic Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2036-0699","authenticated-orcid":true,"given":"Yadu","family":"Vijayan","sequence":"additional","affiliation":[{"name":"Department of Cellular, Molecular and Genetic Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna M.","family":"Tyc","sequence":"additional","affiliation":[{"name":"Department of 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