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Adv."],"published-print":{"date-parts":[[2026,10,23]]},"abstract":"<jats:p>Omnipresent in biology, fibrous networks like collagen possess unique properties: dynamic network via crosslinking and degradation. This intrinsic adaptivity plays a critical role in regulating cell behavior via cell-matrix interactions. Built from biological building blocks, however, these networks are challenging to manipulate or even control. Here, we introduce dynamic network regulation via photochemical control in a synthetic and fibrous highly biomimetic hydrogel. As a proof-of-concept, we demonstrate that the dynamic control over the mechanical properties of this adaptive in vitro model can be used to modulate cell spreading and mechanotransduction in three-dimensional (3D) mesenchymal stromal cell cultures. 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