{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T18:35:33Z","timestamp":1787337333178,"version":"build-2736575974"},"reference-count":62,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"34","funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1120808"],"award-info":[{"award-number":["APP1120808"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP2008715"],"award-info":[{"award-number":["APP2008715"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003550","name":"Queensland Government","doi-asserted-by":"publisher","award":["ESG2142023"],"award-info":[{"award-number":["ESG2142023"]}],"id":[{"id":"10.13039\/501100003550","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Australian Institute of Tropical Health and Medicine"},{"name":"Tropical Australian Academic Health Centre","award":["SF0000921"],"award-info":[{"award-number":["SF0000921"]}]}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2026,8,21]]},"abstract":"<jats:p>\n                    A 3-week delay in the onset of T cell immunity to\n                    <jats:italic toggle=\"yes\">Mycobacterium tuberculosis<\/jats:italic>\n                    (\n                    <jats:italic toggle=\"yes\">Mtb<\/jats:italic>\n                    ) infection compromises lung bacterial control, resulting in tuberculosis (TB). Restoring T cell function is a priority. We identified how airway CD44\n                    <jats:sup>+<\/jats:sup>\n                    CD62L\n                    <jats:sup>\u2212<\/jats:sup>\n                    KLRG1\n                    <jats:sup>+<\/jats:sup>\n                    CD8\n                    <jats:sup>+<\/jats:sup>\n                    effector memory T cells (T\n                    <jats:sub>EM<\/jats:sub>\n                    ) in the lung enhance mycobacterial clearance via the spleen. Unexpectedly, a secondary immune response following repeated exposure of mice to Bacille Calmette-Gu\u00e9rin generated lower numbers of T\n                    <jats:sub>EM<\/jats:sub>\n                    versus primary. Paradoxically, lower numbers correlated with faster bacterial clearance, due to enhanced trafficking of secondary T\n                    <jats:sub>EM<\/jats:sub>\n                    to the spleen, where they responded to antigen. Further, secondary T\n                    <jats:sub>EM<\/jats:sub>\n                    recruited dendritic cells, which accelerated bacterial translocation from the lung to the spleen. Treating mice with a threshold number of airway-derived secondary T\n                    <jats:sub>EM<\/jats:sub>\n                    significantly reduced\n                    <jats:italic toggle=\"yes\">Mtb<\/jats:italic>\n                    burden in the lung and spleen. Notably,\n                    <jats:italic toggle=\"yes\">Mtb<\/jats:italic>\n                    killing was expedited by at least 15 days. Repeated antigen encounter bypassed priming requirements and enhanced T\n                    <jats:sub>EM<\/jats:sub>\n                    durability, uncovering a spleen-centered protective mechanism with implications for improved TB vaccines and therapies.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.aec7792","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T17:58:41Z","timestamp":1787335121000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Antigen-experienced airway CD8\n                    <sup>+<\/sup>\n                    effector memory T cells promote a detour pathway for mycobacterial killing in the spleen"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3367-1196","authenticated-orcid":true,"given":"Julia","family":"Seifert","sequence":"first","affiliation":[{"name":"Australian Institute of Tropical Health and Medicine, James Cook University, Cairns and Townsville, Queensland, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Visai","family":"Muruganandah","sequence":"additional","affiliation":[{"name":"Australian Institute of Tropical Health and Medicine, James Cook University, Cairns and Townsville, Queensland, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9527-0034","authenticated-orcid":true,"given":"Socorro","family":"Miranda-Hernandez","sequence":"additional","affiliation":[{"name":"Australian Institute of Tropical Health and Medicine, James Cook University, Cairns and Townsville, Queensland, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3274-2626","authenticated-orcid":true,"given":"Harindra D.","family":"Sathkumara","sequence":"additional","affiliation":[{"name":"Australian Institute of Tropical Health and Medicine, James Cook University, Cairns and Townsville, Queensland, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3907-5806","authenticated-orcid":true,"given":"Ana Maria","family":"Valencia-Hernandez","sequence":"additional","affiliation":[{"name":"Australian Institute of Tropical Health and Medicine, James Cook University, Cairns and Townsville, Queensland, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1571-3997","authenticated-orcid":true,"given":"Saparna","family":"Pai","sequence":"additional","affiliation":[{"name":"Australian Institute of Tropical Health and Medicine, James Cook University, Cairns and Townsville, Queensland, Australia."},{"name":"TAARA Therapeutics Pty Ltd, Cairns, Queensland, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9259-7873","authenticated-orcid":true,"given":"Andreas","family":"Kupz","sequence":"additional","affiliation":[{"name":"Australian Institute of Tropical Health and Medicine, James Cook University, Cairns and Townsville, Queensland, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","unstructured":"World Health Organization Global Tuberculosis Report 2024 (2025); 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