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Adv."],"published-print":{"date-parts":[[2026,6,12]]},"abstract":"<jats:p>\n                    Succinate, a mitochondrial metabolite, also functions as an extracellular signal through its receptor succinate receptor 1 (SUCNR1), coordinating responses to nutrient availability. The physiological role of SUCNR1 within hepatocytes, however, is unclear. We show that hepatic succinate levels and\n                    <jats:italic toggle=\"yes\">Sucnr1<\/jats:italic>\n                    expression are dynamically regulated by nutritional status. Mice lacking\n                    <jats:italic toggle=\"yes\">Sucnr1<\/jats:italic>\n                    in hepatocytes [Hep-\n                    <jats:italic toggle=\"yes\">Sucnr1<\/jats:italic>\n                    knockout (KO)] exhibit a fasting-like phenotype characterized by enhanced gluconeogenesis, elevated amino acids, and impaired metabolic flexibility. Mechanistically, loss of\n                    <jats:italic toggle=\"yes\">Sucnr1<\/jats:italic>\n                    compromises glucose-derived oxidative flux through the tricarboxylic acid cycle, increases reliance on glutamine-dependent anaplerosis, and induces mitochondrial stress adaptations. Upon refeeding, Hep-\n                    <jats:italic toggle=\"yes\">Sucnr1<\/jats:italic>\n                    KO mice show blunted mammalian target of rapamycin activation, incomplete glycogen restoration, and an altered hepatic proteomic response.\n                    <jats:italic toggle=\"yes\">Sucnr1<\/jats:italic>\n                    expression increases during liver maturation, is enriched in pericentral hepatocytes, and its loss is associated with functional reprogramming of pericentral metabolic functions without disruption of zonation. Together, our findings establish SUCNR1 as a critical regulator of hepatic metabolic adaptation, linking succinate signaling to mitochondrial flexibility and nutrient-dependent metabolic responses.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.aec8873","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T17:58:47Z","timestamp":1781287127000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":0,"title":["SUCNR1 coordinates metabolic flux, mitochondrial function, and nutrient-dependent adaptation in hepatocytes"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9521-6522","authenticated-orcid":true,"given":"Anna","family":"Marsal-Beltran","sequence":"first","affiliation":[{"name":"Institut de Recerca Biom\u00e8dica Catalunya Sud (formerly Institut d\u2019Investigaci\u00f3 Sanit\u00e0ria Pere Virgili), Hospital Universitari Joan XXIII, Tarragona 43005, Spain."},{"name":"CIBER de Diabetes y Enfermedades Metab\u00f3licas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid 28029, Spain."},{"name":"Rovira i Virgili University, Reus 43201, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2895-4601","authenticated-orcid":true,"given":"Laura","family":"Salmer\u00f3n-Pelado","sequence":"additional","affiliation":[{"name":"Institut de Recerca Biom\u00e8dica Catalunya Sud (formerly Institut d\u2019Investigaci\u00f3 Sanit\u00e0ria Pere Virgili), Hospital Universitari Joan XXIII, Tarragona 43005, Spain."},{"name":"CIBER de Diabetes y Enfermedades Metab\u00f3licas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid 28029, Spain."},{"name":"Rovira i Virgili University, Reus 43201, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleix","family":"Ribas-Latre","sequence":"additional","affiliation":[{"name":"Institut de Recerca Biom\u00e8dica Catalunya Sud 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