{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:45:38Z","timestamp":1790635538428,"version":"4.1.0"},"reference-count":40,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"17","license":[{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.science.org\/content\/page\/science-licenses-journal-article-reuse"}],"funder":[{"DOI":"10.13039\/100000015","name":"U.S. Department of Energy","doi-asserted-by":"publisher","award":["ER46430"],"award-info":[{"award-number":["ER46430"]}],"id":[{"id":"10.13039\/100000015","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000015","name":"U.S. Department of Energy","doi-asserted-by":"publisher","award":["DE-SC0022326"],"award-info":[{"award-number":["DE-SC0022326"]}],"id":[{"id":"10.13039\/100000015","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000181","name":"Air Force Office of Scientific Research","doi-asserted-by":"publisher","award":["FA9550-21-1-0418"],"award-info":[{"award-number":["FA9550-21-1-0418"]}],"id":[{"id":"10.13039\/100000181","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006961","name":"California Institute of Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006961","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001742","name":"United States-Israel Binational Science Foundation","doi-asserted-by":"publisher","award":["3013006682"],"award-info":[{"award-number":["3013006682"]}],"id":[{"id":"10.13039\/501100001742","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001742","name":"United States-Israel Binational Science Foundation","doi-asserted-by":"publisher","award":["3013006682"],"award-info":[{"award-number":["3013006682"]}],"id":[{"id":"10.13039\/501100001742","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Israeli ministry of science","award":["MOS 0005959"],"award-info":[{"award-number":["MOS 0005959"]}]},{"name":"Harold Perlman Family"},{"name":"William H. Hurt Scholarship Program"}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2026,4,24]]},"abstract":"<jats:p>\n                    Two fundamental questions have puzzled scientists for more than 150 years. \u201cHow did life become homochiral?\u201d and \u201cwhy was this specific handedness selected?\u201d Recently, it has been shown that homochirality could have emerged through the enantioselective interactions of molecules with magnetic substrates due to the asymmetric crystallization of an RNA precursor on a magnetite substrate, abundant on early Earth. This phenomenon is based on the chirality-induced spin selectivity (CISS) effect. Despite its robustness, this model could not provide an answer to the second question: Why one specific handedness (D for RNA) was selected. Here, we demonstrate that spin-involving processes can have different outcomes in the two enantiomers of chiral molecules. In chiral molecules with unpaired electrons or while electrons are passing through them, the total angular momentum vector,\n                    <jats:bold>J<\/jats:bold>\n                    , is aligned along the \u201ceasy axis,\u201d which is defined by the magnetic anisotropy induced by the spin-orbit coupling and asymmetry of the molecular field. The magnitude\n                    <jats:bold>J<\/jats:bold>\n                    is the same for both enantiomers, but the vectors may be aligned differently relative to the molecular frame in the two enantiomers. This difference can be quantified by, for example, by the angle between\n                    <jats:bold>J<\/jats:bold>\n                    and electric dipole moment of the molecule,\n                    <jats:bold>\u03bc<\/jats:bold>\n                    . We show by direct measurements, theory, and ab initio calculations that dynamic spin processes in chiral molecules could result in different efficiencies of spin-related phenomena, including the interaction of chiral molecules with magnetic surfaces. The findings may provide an explanation for the specific homochirality in nature.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.aec9325","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T17:59:52Z","timestamp":1776880792000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":6,"title":["Dynamic breaking of mirror symmetry in spin-dependent electron transport through chiral media causes enantiomeric excesses"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8739-9952","authenticated-orcid":true,"given":"Yossi","family":"Paltiel","sequence":"first","affiliation":[{"name":"Applied Physics Institute, Center for Nanoscience and Nanotechnology, Hebrew University of Jerusalem, Jerusalem 91904, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8664-246X","authenticated-orcid":true,"given":"Daniel","family":"Goldberg","sequence":"additional","affiliation":[{"name":"Applied Physics Institute, Center for Nanoscience and Nanotechnology, Hebrew University of Jerusalem, Jerusalem 91904, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2933-4721","authenticated-orcid":true,"given":"Nir","family":"Yuran","sequence":"additional","affiliation":[{"name":"Applied Physics Institute, Center for Nanoscience and Nanotechnology, Hebrew University of Jerusalem, Jerusalem 91904, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shira","family":"Yochelis","sequence":"additional","affiliation":[{"name":"Applied Physics Institute, Center for Nanoscience and Nanotechnology, Hebrew University of Jerusalem, Jerusalem 91904, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8742-9972","authenticated-orcid":true,"given":"Jia Hao","family":"Soh","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Southern California, Los Angeles, CA 90089, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1513-1364","authenticated-orcid":true,"given":"Christopher","family":"Seibel","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Southern California, Los Angeles, CA 90089, USA."},{"name":"Department of Physics and Research Center OPTIMAS, RPTU Kaiserslautern-Landau, 67663 Kaiserslautern, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6432-9345","authenticated-orcid":true,"given":"J\u00fcrgen","family":"Gauss","sequence":"additional","affiliation":[{"name":"Department Chemie, Johannes Gutenberg-Universit\u00e4t Mainz, 55128 Mainz, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1227-7539","authenticated-orcid":true,"given":"Shmuel","family":"Zilberg","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences, Ariel University, Ariel 4076414, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1830-3619","authenticated-orcid":true,"given":"S. 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