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Responders displayed enrichment of antigen presentation\/interferon program and coordinated T and B cell expansion, whereas nonresponders retained stable neural crest\u2013like clusters. Epigenetic therapy reactivated transposable elements, priming innate immunity and enhancing immunogenicity. Nuclear factor of activated T cells, cytoplasmic 2 (NFATC2) emerged as a master regulator of neural crest\u2013like states and resistance; its perturbation promoted differentiation and immunogenicity. 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