{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:47:27Z","timestamp":1792003647815,"version":"4.4.0"},"reference-count":119,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"42","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL144801"],"award-info":[{"award-number":["R01 HL144801"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL126523"],"award-info":[{"award-number":["R01 HL126523"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL151389"],"award-info":[{"award-number":["R01 HL151389"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F32HL159904"],"award-info":[{"award-number":["F32HL159904"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2026,10,16]]},"abstract":"<jats:p>Breathing is a fundamental motor rhythm necessary to sustain life. The rhythm and pattern of breathing arises from the coordination of a rostrocaudally extended ventral respiratory column (VRC) in the medulla. Although recurrent excitation is sufficient for rhythmic bursting in reduced in vitro preparations, comparatively less is understood about how inhibition and excitation interact with feedback circuits to generate the breathing rhythm in vivo. Here, we expand on the classical \u201cinspiratory-off switch\u201d model that inhibitory signaling from lung stretch afferent pathways plays a critical role in generating the breathing rhythm in vivo. We perform high-density extracellular recordings along the length of the VRC during optogenetic and physiological manipulations and apply computational analyses to characterize how these perturbations govern low-dimensional neural dynamics. We show that stimulation of GABAergic afferents of the nucleus of the solitary tract advance or delay breathing in a manner similar to, but quantitatively distinct from, inhibition local to the VRC. We use generative dynamical models to show that inhibitory activity controls respiratory activity through transient stabilization of an attractive region of the low-dimensional manifold corresponding to expiration. Together, these results propose an \u201cinspiratory-off attractor\u201d model that underlies network level control of breathing in vivo.<\/jats:p>","DOI":"10.1126\/sciadv.aed2474","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:59:24Z","timestamp":1792000764000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":0,"title":["An inspiration-off attractor supports the robust and flexible control of breathing"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0186-6394","authenticated-orcid":true,"given":"Nicholas E.","family":"Bush","sequence":"first","affiliation":[{"name":"Norcliffe Foundation Center for Integrative Brain Research, Seattle Children\u2019s Research Institute, Seattle, WA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4071-4572","authenticated-orcid":true,"given":"Luiz M.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Norcliffe Foundation Center for Integrative Brain Research, Seattle Children\u2019s Research Institute, Seattle, WA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2409-0122","authenticated-orcid":true,"given":"Zachary T.","family":"Glovak","sequence":"additional","affiliation":[{"name":"Norcliffe Foundation Center for Integrative Brain Research, Seattle Children\u2019s Research Institute, Seattle, WA, USA."},{"name":"Behavioral Phenotyping Core, Seattle Children\u2019s Research Institute, Seattle, WA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5626-3999","authenticated-orcid":true,"given":"Jan-Marino","family":"Ramirez","sequence":"additional","affiliation":[{"name":"Norcliffe Foundation Center for Integrative Brain Research, Seattle Children\u2019s Research Institute, Seattle, WA, USA."},{"name":"Department of Neurological Surgery, University of Washington, Seattle, WA, USA."},{"name":"Department of Pediatrics, University of Washington, Seattle, WA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1099745"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","unstructured":"G. Buzs\u00e1ki Rhythms of the Brain (Oxford Univ. Press 2006).","DOI":"10.1093\/acprof:oso\/9780195301069.001.0001"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1996.76.3.687"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08010"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2023.02.026"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg.2016.150"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.08.037"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-018-0003-6"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-080317-061756"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2917-06.2006"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0386-23.2023"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-024-01712-5"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2015.02.001"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.adi8081"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2021.12.014"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-090121-014424"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2022.108386"},{"key":"e_1_3_2_19_2","doi-asserted-by":"crossref","unstructured":"J. Jhang S. Liu D. D. O\u2019Keefe S. Han A top-down slow breathing circuit that alleviates negative affect. bioRxiv [Preprint] (2023); https:\/\/biorxiv.org\/content\/10.1101\/2023.02.25.529925v1.","DOI":"10.1101\/2023.02.25.529925"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2025.102974"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2012.11.004"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00589-2"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1900523116"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.08.001"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1006148"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3916-07.2008"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1683005"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/75776"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1998.895bs.x"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00830.2011"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.07.003"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3938"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn0901-927"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2104"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2020.00058"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.24415"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1983.55.6.1647"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2006.04981.x"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1923.sp002052"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1993.74.6.2801"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2005.05.003"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00985.2007"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1949.158.2.157"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00475.2024"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.83654"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-021522-094142"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1205295"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00035.2013"},{"key":"e_1_3_2_49_2","doi-asserted-by":"crossref","unstructured":"Y. I. Molkov A. Borgmann H. Koizumi N. Hama R. Zhang J. C. Smith Inference technique for the synaptic conductances in rhythmically active networks and application to respiratory central pattern generation circuits. bioRxiv 2024\u201308 [Preprint] (2024); https:\/\/biorxiv.org\/content\/10.1101\/2024.08.12.607656v3.","DOI":"10.7554\/eLife.101959.1"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2020.02.005"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.6390-11.2013"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4574-12.2013"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1002\/neu.20050"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2318757121"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05144-8"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(01)00581-4"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1990.sp018171"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature20793"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(98)00031-8"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03223-x"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1972.sp009797"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.125336"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202412822"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-023-01520-3"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-025-02031-z"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.05.025"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05293-w"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.90958.2008"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2004.05.032"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(96)12968-2"},{"key":"e_1_3_2_71_2","unstructured":"J. Breuer Die Selbststeuerung Der Athmung Durch Den Nervus Vagus (1868). [The self-regulation of breathing by the vagal nerve]."},{"key":"e_1_3_2_72_2","unstructured":"S. Linderman M. Johnson A. Miller R. Adams D. Blei L. Paninski \u201cBayesian learning and inference in recurrent switching linear dynamical systems \u201d in Artificial Intelligence and Statistics (PMLR 2017) pp. 914\u2013922."},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.11.027"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature18944"},{"key":"e_1_3_2_75_2","first-page":"823","article-title":"Kinematics of the ribbon fin in hovering and swimming of the electric ghost knifefish","volume":"216","author":"Ruiz-Torres R.","year":"2013","unstructured":"R. Ruiz-Torres, O. M. Curet, G. V. Lauder, M. A. MacIver, Kinematics of the ribbon fin in hovering and swimming of the electric ghost knifefish. J. Exp. Biol. 216, 823\u2013834 (2013).","journal-title":"J. Exp. Biol."},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.01020.2002"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1939.2.6.533"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.2040-4603.2012.tb00457.x"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1992.263.4.R962"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2004.03.020"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1162\/neco_a_01586"},{"key":"e_1_3_2_82_2","unstructured":"A. Vermani J. Nassar H. Jeon M. Dowling I. M. Park \u201cMeta-dynamical state space models for integrative neural data analysis \u201d in International Conference on Learning Representations (2025) vol. 2025 pp. 84623\u201384646."},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00039.2015"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00252.2006"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2009.0080"},{"key":"e_1_3_2_86_2","doi-asserted-by":"crossref","unstructured":"Y. Qian J. Li S. Zhao E. Matthews M. Adoff W. Zhong X. An M. Yeo C. Park B.-S. Wang D. Southwell Z. J. Huang Programmable RNA sensing for cell monitoring and manipulation. bioRxiv 2022\u201305 [Preprint] (2022); https:\/\/biorxiv.org\/content\/10.1101\/2022.05.25.493141v1.","DOI":"10.1101\/2022.05.25.493141"},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-022-01534-5"},{"key":"e_1_3_2_88_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06808-9"},{"key":"e_1_3_2_89_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.05.032"},{"key":"e_1_3_2_90_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2008.07.014"},{"key":"e_1_3_2_91_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1997.77.4.1853"},{"key":"e_1_3_2_92_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06812-z"},{"key":"e_1_3_2_93_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.90414.2008"},{"key":"e_1_3_2_94_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2012.00223"},{"key":"e_1_3_2_95_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2000.00207.x"},{"key":"e_1_3_2_96_2","doi-asserted-by":"crossref","unstructured":"S. C. Nuding L. S. Segers K. E. Iceman R. O\u2019Connor J. B. Dean P. A. Valarezo D. Shuman I. C. Solomon D. C. Bolser K. F. Morris B. G. Lindsey Hypoxia evokes a sequence of raphe-pontomedullary network operations for inspiratory drive amplification and gasping. bioRxiv 2023\u201311 [Preprint] (2023); https:\/\/biorxiv.org\/content\/10.1101\/2023.11.07.566027v2.full.","DOI":"10.1101\/2023.11.07.566027"},{"key":"e_1_3_2_97_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200006050-00023"},{"key":"e_1_3_2_98_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00322.2007"},{"key":"e_1_3_2_99_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1006938"},{"key":"e_1_3_2_100_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00081.2002"},{"key":"e_1_3_2_101_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-08-03538.2003"},{"key":"e_1_3_2_102_2","first-page":"955","article-title":"Response of pulmonary rapidly adapting receptors during lung inflation","volume":"55","author":"Pack A.","year":"1983","unstructured":"A. Pack, R. DeLaney, Response of pulmonary rapidly adapting receptors during lung inflation. J. Appl. Neurophysiol. 55, 955\u2013963 (1983).","journal-title":"J. Appl. Neurophysiol."},{"key":"e_1_3_2_103_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2020.103595"},{"key":"e_1_3_2_104_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05139-5"},{"key":"e_1_3_2_105_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2018.00063"},{"key":"e_1_3_2_106_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2021.09.015"},{"key":"e_1_3_2_107_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00056408"},{"key":"e_1_3_2_108_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2000.88.6.2287"},{"key":"e_1_3_2_109_2","doi-asserted-by":"publisher","DOI":"10.1113\/JP274357"},{"key":"e_1_3_2_110_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1976.sp011563"},{"key":"e_1_3_2_111_2","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(72)90051-5"},{"key":"e_1_3_2_112_2","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(80)90021-3"},{"key":"e_1_3_2_113_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1982.53.1.185"},{"key":"e_1_3_2_114_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2023.08.041"},{"key":"e_1_3_2_115_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature13665"},{"key":"e_1_3_2_116_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07915-x"},{"key":"e_1_3_2_117_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.61834"},{"key":"e_1_3_2_118_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-024-02232-7"},{"key":"e_1_3_2_119_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2014.00092"},{"key":"e_1_3_2_120_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.04.007"}],"container-title":["Science Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciadv.aed2474","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:02:22Z","timestamp":1792000942000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciadv.aed2474"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,16]]},"references-count":119,"journal-issue":{"issue":"42","published-print":{"date-parts":[[2026,10,16]]}},"alternative-id":["10.1126\/sciadv.aed2474"],"URL":"https:\/\/doi.org\/10.1126\/sciadv.aed2474","relation":{},"ISSN":["2375-2548"],"issn-type":[{"value":"2375-2548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,16]]},"assertion":[{"value":"2025-10-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eaed2474"}}