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Adv."],"published-print":{"date-parts":[[2026,8,21]]},"abstract":"<jats:p>\n                    Soil salinization poses a major threat to global agricultural productivity and plant biodiversity. The phytohormone abscisic acid (ABA) is central to plant adaptation to abiotic stress; however, the mechanisms by which ABA coordinates posttranslational modifications of signaling proteins with epigenetic regulation remain poorly understood. Here, we show that salt stress\u2013induced ABA accumulation up-regulates\n                    <jats:italic toggle=\"yes\">Heat Shock Factor 4<\/jats:italic>\n                    (\n                    <jats:italic toggle=\"yes\">CmHSFA4<\/jats:italic>\n                    ), a gene that is known to enhance chrysanthemum salt tolerance. The ABA responsive transcription factor ABRE binding factor 1 (CmABF1) binds to the\n                    <jats:italic toggle=\"yes\">CmHSFA4<\/jats:italic>\n                    promoter to activate its expression and also recruits the chromatin remodeler BRAHMA (CmBRM) to repress transcription by limiting H3 lysine-4 trimethylation (H3K4me3) deposition. We further demonstrate that the ABA-activated sucrose non-fermenting-1-related protein kinase 2.2 (CmSnRK2.2) phosphorylates and stabilizes CmABF1, while concurrently phosphorylating and promoting CmBRM degradation under salt stress. This dual regulation enhances H3K4me3 enrichment at the\n                    <jats:italic toggle=\"yes\">CmHSFA4<\/jats:italic>\n                    promoter, thereby inducing its transcription and conferring salt tolerance. Together, our findings reveal an ABA-SnRK2.2-ABF1\/BRM signaling module that integrates phosphorylation-dependent protein stabilization and degradation with histone methylation dynamics to fine-tune salt stress\u2013responsive gene expression in chrysanthemum.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.aed2521","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T17:58:41Z","timestamp":1787335121000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":1,"title":["Abscisic acid\u2013regulated stability of CmABF1 and CmBRM modulates salt tolerance in chrysanthemum via epigenetic regulation of\n                    <i>CmHSFA4<\/i>"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6273-6609","authenticated-orcid":true,"given":"Xinhui","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Crop Genetics and Germplasm Enhancement, 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