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The brown treesnake (\n                    <jats:italic toggle=\"yes\">Boiga irregularis<\/jats:italic>\n                    ) in Guam represents a notable example of this phenomenon, having been introduced with only a handful of individuals. We show that the population endured an extreme bottleneck, with roughly half of the genome exhibiting runs of homozygosity, comparable to species of conservation concern. Despite this, we uncovered extensive diversity in the form of nearly 19,000 genomic structural variants, which affect almost eight times more of the genome than single-nucleotide variants and provide material for \u201crescuing\u201d the population from inbreeding-driven declines. Structural variant density was highest in gene promoters, where recombination and DNA repair often occur, providing a mechanism for rapid evolution of gene-linked diversity. This diversity is enriched in genes vital for adaptive immunity and olfaction, suggesting genomic diversity in key chromosomal regions can rescue populations from inbreeding. This work has critical implications for invasion biology and conservation genetics practitioners.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.aed3656","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T17:58:33Z","timestamp":1784915913000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Genomic structural variation rescues a classic biological invader from a population bottleneck"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6387-5451","authenticated-orcid":true,"given":"Christopher A.","family":"Osborne","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, University at Buffalo, Buffalo, NY, 14260, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6133-1602","authenticated-orcid":true,"given":"Brian M.","family":"Foote","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University at Buffalo, Buffalo, NY, 14260, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5370-2258","authenticated-orcid":true,"given":"Steven J.","family":"Fleck","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University at Buffalo, Buffalo, NY, 14260, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8991-1059","authenticated-orcid":true,"given":"Hannah M.","family":"Waterman","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University at Buffalo, Buffalo, NY, 14260, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7280-8664","authenticated-orcid":true,"given":"Sarah L.","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University at Buffalo, Buffalo, NY, 14260, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7325-3055","authenticated-orcid":true,"given":"Melia G.","family":"Nafus","sequence":"additional","affiliation":[{"name":"U.S. Geological Survey, Pacific Island Ecosystems Research Center, Hawaii National Park, Hawaii, HI 96718, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5274-9572","authenticated-orcid":true,"given":"M. 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