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Accordingly, deletion of\n                    <jats:italic toggle=\"yes\">CASP-8<\/jats:italic>\n                    robustly enhanced entry to senescence and prolonged the life span of senescent cells. cIAP-2, which inhibits death receptor\u2013driven cell death, was also up-regulated in senescent cells, and deletion of IAPs suppressed entry to senescence. Consistent with this, small-molecule IAP antagonists exhibited potent senolytic activity through enhancing death receptor\u2013initiated Caspase-8 activation. 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