{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T00:00:59Z","timestamp":1787356859248,"version":"build-2736575974"},"reference-count":11,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"51","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2025,12,19]]},"abstract":"<jats:p>When two genes linked to increased Parkinson\u2019s risk converge on a lysosome, LRRK2 mutation enhances lysosomal release of soluble GPNMB potentially contributing to synuclein pathology.<\/jats:p>","DOI":"10.1126\/sciadv.aed8002","type":"journal-article","created":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T18:59:52Z","timestamp":1765997992000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":4,"title":["GPNMB, LRRK2, and lysosome exocytosis in Parkinson\u2019s"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6462-984X","authenticated-orcid":true,"given":"Suzanne R.","family":"Pfeffer","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305-5307, USA and Aligning Science Across Parkinson\u2019s, Chevy Chase, MD 20815 USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10048-017-0514-8"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abk0637"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2021.105494"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-07415-6"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adv1434"},{"key":"e_1_3_1_7_2","doi-asserted-by":"crossref","unstructured":"S. R. Pfeffer D. R. Alessi \u201cLeucine-rich repeat kinase 2: Pathways to Parkinson\u2019s disease. In Parkinson\u2019s Disease\u201d in Cold Spring Harbor Perspectives in Medicine (Cold Spring Harbor Laboratory Press ed. 2 2025) pp. 133\u2013150.","DOI":"10.1101\/cshperspect.a041620"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2019.05.003"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1812196115"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2025.102482"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2421886122"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12084"}],"container-title":["Science Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciadv.aed8002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T19:00:34Z","timestamp":1765998034000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciadv.aed8002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,19]]},"references-count":11,"journal-issue":{"issue":"51","published-print":{"date-parts":[[2025,12,19]]}},"alternative-id":["10.1126\/sciadv.aed8002"],"URL":"https:\/\/doi.org\/10.1126\/sciadv.aed8002","relation":{},"ISSN":["2375-2548"],"issn-type":[{"value":"2375-2548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,19]]},"assertion":[{"value":"2025-11-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eaed8002"}}