{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:31:22Z","timestamp":1792153882842,"version":"4.4.0"},"reference-count":76,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"39","funder":[{"DOI":"10.13039\/501100001742","name":"United States-Israel Binational Science Foundation","doi-asserted-by":"publisher","award":["2018050"],"award-info":[{"award-number":["2018050"]}],"id":[{"id":"10.13039\/501100001742","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["12374356"],"award-info":[{"award-number":["12374356"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["11974265"],"award-info":[{"award-number":["11974265"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["BX20240267"],"award-info":[{"award-number":["BX20240267"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Key Research and Development Program of China","award":["2020YFA0211300"],"award-info":[{"award-number":["2020YFA0211300"]}]},{"name":"Nanoscale and Quantum Phenomena Institute at Ohio University","id":[{"id":"https:\/\/ror.org\/01jr3y717","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2026,9,25]]},"abstract":"<jats:p>\n                    Chiral sensing is vital in pharmaceuticals and biomedicine but is hindered by the inherently weak chiroptic signals of molecules. Conventional methods rely on tedious chromatographic techniques with expensive chiral columns. This work introduces a breakthrough in ultrasensitive chiral detection by combining nonlinear optics and tailored chiral plasmonics. We fabricate spiral gold metastructures that provide strong enhancements of both electric and superchiral near fields, which simultaneously optimize both the nonlinear conversion efficiency and dissymmetry factor, thereby generating a prominent nonlinear chiroptic response to chiral molecules. The resulting change of circularly polarized second-harmonic generation (\u0394CP\n                    <jats:sub>SHG<\/jats:sub>\n                    ) demonstrates remarkable sensitivity to chiral adsorbates, achieving a record-low detection limit of \u223c11 picomolars and an outstanding figure of merit of 3260\u00a0per micromolar. A key advantage is the ability to selectively detect specific enantiomers directly within racemic mixtures, thereby dispensing with the need for preliminary chromatographic separation. This platform opens promising avenues for chiral analysis, pushing the boundaries of sensitivity, selectivity, and miniaturization for next-generation biochemical assays.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.aed9129","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:59:49Z","timestamp":1790186389000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":1,"title":["Ultrasensitive chiral detection by nonlinear chiroptics in spiral plasmonic metastructures surpasses linear limits"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0086-4497","authenticated-orcid":true,"given":"Yong","family":"Tan","sequence":"first","affiliation":[{"name":"Key Laboratory of Artificial Micro\/Nano Structure of Ministry of Education, School of Physics and Technology, Wuhan University, Wuhan 430072, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5457-8779","authenticated-orcid":true,"given":"Yufeng","family":"Cheng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Artificial Micro\/Nano Structure of Ministry of Education, School of Physics and Technology, Wuhan University, Wuhan 430072, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6858-7587","authenticated-orcid":true,"given":"Xiaolin","family":"Lu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Artificial Micro\/Nano Structure of Ministry of Education, School of Physics and Technology, Wuhan University, Wuhan 430072, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8284-9494","authenticated-orcid":true,"given":"Huatian","family":"Hu","sequence":"additional","affiliation":[{"name":"Center for Biomolecular Nanotechnologies, Istituto Italiano di Tecnologia, Arnesano 73010, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3586-6408","authenticated-orcid":true,"given":"Xiaoze","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Artificial Micro\/Nano Structure of Ministry of Education, School of Physics and Technology, Wuhan University, Wuhan 430072, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1316-6758","authenticated-orcid":true,"given":"Alexander","family":"Govorov","sequence":"additional","affiliation":[{"name":"Department of Physics and Astronomy, Ohio University, Athens, OH 45701, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1817-3327","authenticated-orcid":true,"given":"Tao","family":"Ding","sequence":"additional","affiliation":[{"name":"Key Laboratory of Artificial Micro\/Nano Structure of Ministry of Education, School of Physics and Technology, Wuhan University, Wuhan 430072, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-04243-2"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12210-012-0220-2"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42254-021-00391-6"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/adom.201700182"},{"key":"e_1_3_2_6_2","unstructured":"H. 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