{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T18:55:48Z","timestamp":1781290548621,"version":"3.54.1"},"reference-count":62,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"24","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32571064"],"award-info":[{"award-number":["32571064"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170748"],"award-info":[{"award-number":["82170748"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32171464"],"award-info":[{"award-number":["32171464"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82130074"],"award-info":[{"award-number":["82130074"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82250710179"],"award-info":[{"award-number":["82250710179"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003395","name":"Shanghai Municipal Education Commission","doi-asserted-by":"publisher","award":["2021-01-07-00-02-E00090"],"award-info":[{"award-number":["2021-01-07-00-02-E00090"]}],"id":[{"id":"10.13039\/501100003395","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 111-2314-B-039-056"],"award-info":[{"award-number":["MOST 111-2314-B-039-056"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["NSTC 113-2314-B-039-073-MY3"],"award-info":[{"award-number":["NSTC 113-2314-B-039-073-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National key R&D program of China","doi-asserted-by":"crossref","award":["2024YFC3506200"],"award-info":[{"award-number":["2024YFC3506200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100018625","name":"Science and Technology Innovation Plan Of Shanghai Science and Technology Commission","doi-asserted-by":"publisher","award":["23ZR1455400"],"award-info":[{"award-number":["23ZR1455400"]}],"id":[{"id":"10.13039\/501100018625","id-type":"DOI","asserted-by":"publisher"}]},{"name":"FPRC 5 per mille Ministero della Salute","award":["2017 PTCRC-Intra 2020"],"award-info":[{"award-number":["2017 PTCRC-Intra 2020"]}]},{"name":"FPRC 5 per mille Ministero della Salute","award":["2018 ADVANCE"],"award-info":[{"award-number":["2018 ADVANCE"]}]},{"name":"FPRC 5 per mille Ministero della Salute","award":["2022 CARESS"],"award-info":[{"award-number":["2022 CARESS"]}]},{"DOI":"10.13039\/501100003196","name":"Italian Ministry of Health","doi-asserted-by":"crossref","award":["Ricerca Corrente 2025"],"award-info":[{"award-number":["Ricerca Corrente 2025"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005010","name":"Fondazione AIRC per la Ricerca sul Cancro","doi-asserted-by":"crossref","award":["Grant IG 2023 ID 28933"],"award-info":[{"award-number":["Grant IG 2023 ID 28933"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100020732","name":"Innovative Research Team of High Level Local Universities in Shanghai","doi-asserted-by":"crossref","award":["SHSMUZDCX20212000"],"award-info":[{"award-number":["SHSMUZDCX20212000"]}],"id":[{"id":"10.13039\/100020732","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100020930","name":"Ministry of Education, Kenya","doi-asserted-by":"publisher","award":["KFKT20250001"],"award-info":[{"award-number":["KFKT20250001"]}],"id":[{"id":"10.13039\/501100020930","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018625","name":"Science and Technology Innovation Plan Of Shanghai Science and Technology Commission","doi-asserted-by":"publisher","award":["24ZR1492400"],"award-info":[{"award-number":["24ZR1492400"]}],"id":[{"id":"10.13039\/501100018625","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2026,6,12]]},"abstract":"<jats:p>\n                    Endoplasmic reticulum stress (ERS) and autophagy regulate tumor-infiltrating T cell function and exhaustion, but the underlying mechanisms remain unclear. Here, we identified the ERS-related transmembrane protein TMED4 (transmembrane emp24 domain-containing 4) as a critical regulator of CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell antitumor immunity.\n                    <jats:italic toggle=\"yes\">Tmed4<\/jats:italic>\n                    deletion in T cells enhanced antitumor responses by promoting CD8\n                    <jats:sup>+<\/jats:sup>\n                    T proliferation, infiltration, and killing capacity, while reducing terminal exhaustion. Mechanistically,\n                    <jats:italic toggle=\"yes\">Tmed4<\/jats:italic>\n                    deficiency hyperactivated the inositol-requiring enzyme 1\u03b1 (IRE1\u03b1)\u2013X-box binding protein 1 (XBP1) axis and induced autophagy flux in an IRE1\u03b1-dependent manner. Genetic deletion of\n                    <jats:italic toggle=\"yes\">Ern1<\/jats:italic>\n                    (IRE1\u03b1) or\n                    <jats:italic toggle=\"yes\">Becn1<\/jats:italic>\n                    (Beclin1) impaired the antitumor effects of\n                    <jats:italic toggle=\"yes\">Tmed4<\/jats:italic>\n                    deficiency, underscoring the role of ERS and autophagy in CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell function. Moreover,\n                    <jats:italic toggle=\"yes\">Tmed4<\/jats:italic>\n                    -deficient chimeric antigen receptor T cells (CAR T cells) displayed improved antitumor immunity. Pharmacological inhibition of\n                    <jats:italic toggle=\"yes\">Tmed4<\/jats:italic>\n                    using antisense oligonucleotide also enhanced CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell\u2013mediated tumor control. In summary, our study reveals that TMED4 governs CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell effector function and limits terminal exhaustion through IRE1\u03b1-driven autophagy, establishing TMED4 as a promising immunotherapeutic target for improving CAR T cell efficacy.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.aee0517","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T17:58:47Z","timestamp":1781287127000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Targeting TMED4 enhances CD8\n                    <sup>+<\/sup>\n                    T cell function and CAR T cell efficacy in solid tumors through the IRE1\u03b1-autophagy axis"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8907-3352","authenticated-orcid":true,"given":"Huizi","family":"Wang","sequence":"first","affiliation":[{"name":"Department of General Surgery, Tongren Hospital &amp; Shanghai Institute of Immunology, Center for Immune-Related Diseases Research at Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6773-0775","authenticated-orcid":true,"given":"Licai","family":"Shi","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemical Oncogenomics, Shenzhen Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen, Guangdong, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7959-7716","authenticated-orcid":true,"given":"Ke","family":"Jiang","sequence":"additional","affiliation":[{"name":"Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China."},{"name":"State Key Laboratory of Systems Medicine for Cancer, Shanghai Jiao Tong University School of Medicine, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7319-3127","authenticated-orcid":true,"given":"Shuyao","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Tongren Hospital &amp; Shanghai Institute of Immunology, Center for Immune-Related Diseases Research at Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Tongren Hospital &amp; Shanghai Institute of Immunology, Center for Immune-Related Diseases Research at Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3820-0553","authenticated-orcid":true,"given":"Yuexiao","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Tongren Hospital &amp; Shanghai Institute of Immunology, Center for Immune-Related Diseases Research at Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Li","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Tongren Hospital &amp; Shanghai Institute of Immunology, Center for Immune-Related Diseases Research at Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4012-8577","authenticated-orcid":true,"given":"Xin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Tongren Hospital &amp; Shanghai Institute of Immunology, Center for Immune-Related Diseases Research at Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiamin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Tongren Hospital &amp; Shanghai Institute of Immunology, Center for Immune-Related Diseases Research at Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6105-9455","authenticated-orcid":true,"given":"Jun","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Tongren Hospital &amp; Shanghai Institute of Immunology, Center for Immune-Related Diseases Research at Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3848-4266","authenticated-orcid":true,"given":"Emily Jiatong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Tongren Hospital &amp; Shanghai Institute of Immunology, Center for Immune-Related Diseases Research at Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3946-8307","authenticated-orcid":true,"given":"Sophia Jiaxin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Tongren Hospital &amp; Shanghai Institute of Immunology, Center for Immune-Related Diseases Research at Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemical Oncogenomics, Shenzhen Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen, Guangdong, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5633-3988","authenticated-orcid":true,"given":"Ming","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Immunology, Zunyi Medical University and Key Laboratory of Cancer Prevention and Treatment of Guizhou Province, Zunyi City, Guizhou Province 563000, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6889-0279","authenticated-orcid":true,"given":"Lin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Immunology, Zunyi Medical University and Key Laboratory of Cancer Prevention and Treatment of Guizhou Province, Zunyi City, Guizhou Province 563000, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chu-Hu","family":"Lai","sequence":"additional","affiliation":[{"name":"Precision Immunotherapy, Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Aicher","sequence":"additional","affiliation":[{"name":"Precision Immunotherapy, Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8332-4710","authenticated-orcid":true,"given":"Youqiong","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Tongren Hospital &amp; Shanghai Institute of Immunology, Center for Immune-Related Diseases Research at Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1158-8554","authenticated-orcid":true,"given":"Christopher","family":"Heeschen","sequence":"additional","affiliation":[{"name":"Pancreatic Cancer Heterogeneity, Candiolo Cancer Institute FPO-IRCCS, Candiolo, Turin, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4368-7757","authenticated-orcid":true,"given":"Yu J.","family":"Cao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemical Oncogenomics, Shenzhen Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen, Guangdong, China."},{"name":"Institute of Chemical Biology, Shenzhen Bay Laboratory, Shenzhen, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6933-7280","authenticated-orcid":true,"given":"Xuefeng","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Tongren Hospital &amp; Shanghai Institute of Immunology, Center for Immune-Related Diseases Research at Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China."},{"name":"Department of Immunology, Zunyi Medical University and Key Laboratory of Cancer Prevention and Treatment of Guizhou Province, Zunyi City, Guizhou Province 563000, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-021-00459-7"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-020-02128-1"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9010059"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12657"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-041015-055318"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1229620"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0312-6"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature19317"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1325-x"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-023-01614-x"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20220686"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09263-1"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1326-9"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0597-x"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3976"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01570-w"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032414-112116"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2019.03.031"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3270"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3025"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.57950"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.03706"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.03.037"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.adf7579"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau0135"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-0793-3"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-0725-2"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2019.11.007"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.109249"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2021.2002101"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.87272"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M709656200"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bspc.2022.103922"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI179874"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0136-1"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202105320"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.12.4.957"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells10061522"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2024-010145"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-020-00312-2"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2018-316595"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-03037-z"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20201217"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.110943"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-14-7"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14049"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cels.2019.03.003"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.04.048"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-019-0619-0"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-29366-6"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-022-01100-4"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.08.003"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.03.023"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2023.09.011"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20200920"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03752-4"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06300-3"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2023.04.011"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1918986117"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2020-002312"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-021-00292-8"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4402"}],"container-title":["Science Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciadv.aee0517","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T18:00:58Z","timestamp":1781287258000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciadv.aee0517"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,12]]},"references-count":62,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2026,6,12]]}},"alternative-id":["10.1126\/sciadv.aee0517"],"URL":"https:\/\/doi.org\/10.1126\/sciadv.aee0517","relation":{},"ISSN":["2375-2548"],"issn-type":[{"value":"2375-2548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,12]]},"assertion":[{"value":"2025-11-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eaee0517"}}