{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:59:43Z","timestamp":1790189983537,"version":"4.1.0"},"reference-count":80,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"39","funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2023-00266120"],"award-info":[{"award-number":["RS-2023-00266120"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2022-NR069145"],"award-info":[{"award-number":["RS-2022-NR069145"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2024-00508718"],"award-info":[{"award-number":["RS-2024-00508718"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2024-00415347"],"award-info":[{"award-number":["RS-2024-00415347"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2025-25396400"],"award-info":[{"award-number":["RS-2025-25396400"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2025-02305555"],"award-info":[{"award-number":["RS-2025-02305555"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Korea Brain Research Institute Intramural Research Fund","award":["26-BR-01-01"],"award-info":[{"award-number":["26-BR-01-01"]}],"id":[{"id":"https:\/\/ror.org\/055zd7d59","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Korea Brain Research Institute Intramural Research Fund","award":["26-BR-05-05"],"award-info":[{"award-number":["26-BR-05-05"]}],"id":[{"id":"https:\/\/ror.org\/055zd7d59","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Korea Brain Research Institute Intramural Research Fund","award":["26-BR-07-01"],"award-info":[{"award-number":["26-BR-07-01"]}],"id":[{"id":"https:\/\/ror.org\/055zd7d59","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2026,9,25]]},"abstract":"<jats:p>\n                    Thalamofrontal (TF) dysconnectivity is one of the most consistent circuit-level abnormalities reported in patients with schizophrenia and is linked to deficits in short-term memory (STM). However, the biological mechanisms underlying TF weakening remain unclear. Here, we show that repeated adolescent\n                    <jats:italic toggle=\"yes\">N<\/jats:italic>\n                    -methyl-\n                    <jats:sc>d<\/jats:sc>\n                    -aspartate receptor (NMDAR) antagonism produces STM deficits by impairing TF synaptic transmission. In mice repeatedly exposed to ketamine, STM impairment coincided with reduced release probability and attenuated short-term depression at mediodorsal thalamus (MD)\u00a0\u2192\u00a0dorsomedial prefrontal cortex (dmPFC) synapses, without detectable changes in corticocortical synaptic release probability, intrinsic excitability, or gross synaptic ultrastructure. These presynaptic deficits were accompanied by diminished direction-selective population coding in the dmPFC and impaired delayed alternation performance. Chemogenetically strengthening MD\u00a0\u2192\u00a0dmPFC projections restored both neural selectivity and behavior. These findings identify a projection-specific presynaptic mechanism through which adolescent NMDAR hypofunction weakens TF communication and produces cognitive impairment, offering a biological explanation for clinically observed TF dysconnectivity and establishing TF synapses as a therapeutic target.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.aee2152","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:59:49Z","timestamp":1790186389000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Thalamofrontal synaptic weakening underlies short-term memory deficits from adolescent NMDAR hypofunction"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7526-898X","authenticated-orcid":true,"given":"Jinseon","family":"Yu","sequence":"first","affiliation":[{"name":"Sensory and Motor Systems Research Group, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea."},{"name":"Department of Brain Sciences, Daegu Gyeongbuk Institute of Science &amp; Technology (DGIST), Daegu, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4189-8542","authenticated-orcid":true,"given":"In Sun","family":"Choi","sequence":"additional","affiliation":[{"name":"Sensory and Motor Systems Research Group, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0503-187X","authenticated-orcid":true,"given":"Gyu Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Neural Circuits Research Group, KBRI, Daegu, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1263-7506","authenticated-orcid":true,"given":"Sangkyu","family":"Bahn","sequence":"additional","affiliation":[{"name":"Cognitive Science Group, KBRI, Daegu, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9766-5874","authenticated-orcid":true,"given":"Jinmo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering and Computer Science, DGIST, Daegu, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9022-8273","authenticated-orcid":true,"given":"Sungwon","family":"Bae","sequence":"additional","affiliation":[{"name":"Sensory and Motor Systems Research Group, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea."},{"name":"Department of Pharmacology, College of Medicine, Yonsei University, Seoul, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2868-5331","authenticated-orcid":true,"given":"Taekwan","family":"Lee","sequence":"additional","affiliation":[{"name":"Brain Research Core Facility, KBRI, Daegu, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2090-8724","authenticated-orcid":true,"given":"Joon Ho","family":"Choi","sequence":"additional","affiliation":[{"name":"Sensory and Motor Systems Research Group, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1060-1462","authenticated-orcid":true,"given":"Jun Soo","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Hanyang University Hospital, Seoul, Republic of Korea."},{"name":"Institute of Human Behavioral Medicine, Seoul National University (SNU) Medical Research Center, Seoul, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8668-0817","authenticated-orcid":true,"given":"Minah","family":"Kim","sequence":"additional","affiliation":[{"name":"Institute of Human Behavioral Medicine, Seoul National University (SNU) Medical Research Center, Seoul, Republic of Korea."},{"name":"Department of Psychiatry, SNU College of Medicine, Seoul, Republic of Korea."},{"name":"Department of Neuropsychiatry, SNU Hospital, Seoul, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9109-3860","authenticated-orcid":true,"given":"Ji-Woong","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering and Computer Science, DGIST, Daegu, Republic of Korea."},{"name":"Brain Engineering Convergence Research Center, DGIST, Daegu, Republic of Korea."},{"name":"Biomedical Science and Engineering, DGIST, Daegu, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1366-4709","authenticated-orcid":true,"given":"Kea Joo","family":"Lee","sequence":"additional","affiliation":[{"name":"Neural Circuits Research Group, KBRI, Daegu, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3780-0522","authenticated-orcid":true,"given":"Jong-Cheol","family":"Rah","sequence":"additional","affiliation":[{"name":"Sensory and Motor Systems Research Group, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea."},{"name":"Department of Brain Sciences, Daegu Gyeongbuk Institute of Science &amp; Technology (DGIST), Daegu, Republic of Korea."},{"name":"Brain Engineering Convergence Research Center, DGIST, Daegu, Republic of Korea."},{"name":"Biomedical Science and Engineering, DGIST, Daegu, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1300.020"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2006.08.013"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbs076"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2015.10.013"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.60.6.572"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2010.02.1069"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2007.05.025"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300438"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurpsyc.1959.02340150095011"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1994.03950030035004"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1992.68.1.345"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-021-01196-w"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2014.01027"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-021-01161-7"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-023-01769-z"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0189287"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-020-0740-6"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81972-8"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.156.9.1358"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(96)00350-2"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/10.9.910"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature22324"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/365753a0"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/20939"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-070815-014006"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4568"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature22073"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.01.038"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.schbul.a033321"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2012.12010056"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2012.147"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2024.101802"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1037\/a0012602"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.10.025"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-3-149"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbl051"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2017.06.013"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.105.091199"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2213-07.2007"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0645-25.2025"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awae374"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4029-05.2005"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/44151"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80789-8"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7638624"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5297-05.2006"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008837311948"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(95)90304-6"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-21-09587.1999"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2023.1153970"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2010.03.003"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.18607"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80146-4"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.1758"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2022.104560"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0308455101"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(02)00298-1"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-092523-110001"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.08.038"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.64567"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.06.018"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-025-01979-2"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2014.12.012"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/18.16.4372"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1163174"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.11.001"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000700"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00994.2003"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.09.022"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4565-14.2015"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13041-020-00608-2"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3003359"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0284-24.2024"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature14445"},{"key":"e_1_3_2_76_2","unstructured":"G. Paxinos K. B. J. Franklin Paxinos and Franklin\u2019s the mouse brain in stereotaxic coordinates in The Coronal Plates and Diagrams (Academic Press ed. 5 2019)."},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsptsci.8b00012"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-41088-2"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-8994-2_10"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2013.155"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2025.102761"}],"container-title":["Science Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciadv.aee2152","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:03:15Z","timestamp":1790186595000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciadv.aee2152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,25]]},"references-count":80,"journal-issue":{"issue":"39","published-print":{"date-parts":[[2026,9,25]]}},"alternative-id":["10.1126\/sciadv.aee2152"],"URL":"https:\/\/doi.org\/10.1126\/sciadv.aee2152","relation":{},"ISSN":["2375-2548"],"issn-type":[{"value":"2375-2548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,25]]},"assertion":[{"value":"2025-11-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eaee2152"}}