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Adv."],"published-print":{"date-parts":[[2026,6,5]]},"abstract":"<jats:p>\n                    DNA offers the promise of high-density, long-term storage, yet current systems face limitations due to polymerase chain reaction\u2013based manual workflows that are inherently slow, error prone, and difficult to scale for practical applications. Here, we present an electric field\u2013guided DNA pool elongation system that addresses these challenges through molecular data control. Our electric field\u2013driven DNA memory chip integrates immobilization for encoding with reusable synthesis access capabilities. Electric field\u2013driven primer access and DNA synthesis were evaluated through position-specific primer hybridization combined with elongation at room temperature, maintaining high fidelity while dramatically reducing access times. This electric field\u2013driven approach exhibited linear degradation, projected to exceed 10\n                    <jats:sup>5<\/jats:sup>\n                    reuse cycles. Using this method with a common primer, we successfully stored and retrieved different DNA pools, enabling one-step next-generation sequencing library preparation. We further retrieved a 0.2\u2013megabyte three-dimensional object encoded in 1339 unique strands, achieving 96.6% perfect matching. The system demonstrates chip-level capacities approaching 1.1\u00a0\u00d7\u00a010\n                    <jats:sup>9<\/jats:sup>\n                    molecules per electrode, representing a significant advancement toward practical, scalable DNA data storage.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.aee4328","type":"journal-article","created":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T17:59:36Z","timestamp":1780682376000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":3,"title":["Electric field\u2013guided random-access DNA data storage"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1201-0571","authenticated-orcid":true,"given":"Doyeon","family":"Lim","sequence":"first","affiliation":[{"name":"Department of Nano-Bioengineering, Incheon National University, Incheon 22012, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7897-4868","authenticated-orcid":true,"given":"Taeseok","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Nano-Bioengineering, Incheon National University, Incheon 22012, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wonjin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Intelligent Semiconductor Engineering, Incheon National University, 119 Academy-ro, Incheon 22012, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeeshan","family":"Haider","sequence":"additional","affiliation":[{"name":"Department of Nano-Bioengineering, Incheon National University, Incheon 22012, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1043-9215","authenticated-orcid":true,"given":"Seunghwan","family":"Noh","sequence":"additional","affiliation":[{"name":"Department of Nano-Bioengineering, Incheon National University, Incheon 22012, Republic of Korea."},{"name":"Department of Bioengineering, Northeastern University Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minsang","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Nano-Bioengineering, Incheon National University, Incheon 22012, Republic of Korea."},{"name":"AptaBio Inc., 1307 Tower Bldg., Heungdeok IT Valley, Yongin 16954, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9133-6308","authenticated-orcid":true,"given":"Xiaohua","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0485-0072","authenticated-orcid":true,"given":"Hyuk Soo","family":"Eun","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, School of Medicine, Chungnam National University, Daejeon 35015, Republic of Korea."},{"name":"Department of Gastroenterology, Chungnam National University Hospital, Daejeon 35015, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9423-6169","authenticated-orcid":true,"given":"Youngjun","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Nano-Bioengineering, Incheon National University, Incheon 22012, Republic of Korea."},{"name":"Department of Intelligent Semiconductor Engineering, Incheon National University, 119 Academy-ro, Incheon 22012, Republic of Korea."},{"name":"Standard Bioelectronics. 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