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The released Zn\n                    <jats:sup>2+<\/jats:sup>\n                    specifically disrupted zinc homeostasis in tumor cells, inducing mitochondrial dysfunction. This effect acted in concert with DDP-mediated DNA damage, not only effectively activating the cGAS-STING (cyclic GMP-AMP synthase\u2013stimulator of interferon genes) pathway but also promoting the assembly and activation of AIM2-PANoptosome complex to execute PANoptosis. This STING-PANoptosis cascade led to a burst release of damage-associated molecular patterns, markedly enhanced dendritic cell maturation, and stimulated the secretion of pro-inflammatory cytokines. Furthermore, the nanodriver elicited a robust antitumor immune response and established durable immune memory in mouse models. These findings not only provide an optimized strategy for precise immunotherapy of gastric cancer but also increase the understanding of the applications of metal ion immunology and PANoptosis in disease intervention.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.aee4577","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:58:26Z","timestamp":1790791106000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Chemo-metallo nanodrivers for spatiotemporally controlled in situ vaccination"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7107-0062","authenticated-orcid":true,"given":"Xianmin","family":"Li","sequence":"first","affiliation":[{"name":"Department of Oncology, Suzhou Xiangcheng People\u2019s Hospital, Suzhou 215131, China."},{"name":"Institute of Functional Nano &amp; Soft Materials (FUNSOM), Jiangsu Key Laboratory of Advanced 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