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Adv."],"published-print":{"date-parts":[[2026,6,26]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">YAP<\/jats:italic>\n                    and its paralog,\n                    <jats:italic toggle=\"yes\">TAZ<\/jats:italic>\n                    , are transcriptional coactivators of the Hippo pathway that regulate cell growth. Their structural distinctiveness suggests important independent functional differences. To investigate this further, we generated YAP- and TAZ-predominant clones in the liver and followed their long-term behavior. YAP clones rapidly dedifferentiate cells into a stem cell\u2013like state with inflammatory immune cell recruitment followed by their clearance. In contrast, TAZ clones promote an anti-inflammatory immune environment, resulting in their long-term maintenance, massive organ growth, and increased mortality. YAP clones recruit inflammatory blood-derived monocytes, which, if inhibited, permits YAP clonal growth. Consistent with these results, patients with\n                    <jats:italic toggle=\"yes\">YAP<\/jats:italic>\n                    <jats:sup>High<\/jats:sup>\n                    colorectal cancer (CRC) had a 67% 5-year survival rate, whereas patients with\n                    <jats:italic toggle=\"yes\">TAZ<\/jats:italic>\n                    <jats:sup>High<\/jats:sup>\n                    CRC did not survive to 5 years. Similar trends were seen in patients with hepatocellular carcinoma. These findings underscore the importance of understanding the intrinsic differences in YAP and TAZ biology as independent drivers of disease.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.aee8580","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T18:00:04Z","timestamp":1782324004000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Inflammatory monocytes constrain YAP-induced cell proliferation"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8883-3872","authenticated-orcid":true,"given":"Serrena","family":"Singh","sequence":"first","affiliation":[{"name":"Section of Pediatric Gastroenterology, Hepatology, and Nutrition, Yale School of Medicine, New Haven, CT 06520, USA."},{"name":"Yale Liver Center, Department of Medicine, Yale School of Medicine, New Haven, CT 06520, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5729-0403","authenticated-orcid":true,"given":"Nareh","family":"Tahmasian","sequence":"additional","affiliation":[{"name":"Program in Neuroscience and Mental Health, SickKids Research Institute, Toronto, ON M5G 1L7, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3677-613X","authenticated-orcid":true,"given":"Jia-Jun","family":"Liu","sequence":"additional","affiliation":[{"name":"Organ Pathobiology and Therapeutics Institute, Department of Pharmacology and Chemical Biology, Pittsburgh Liver Research Center, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjia","family":"Wang","sequence":"additional","affiliation":[{"name":"Organ Pathobiology and Therapeutics Institute, Department of Pharmacology and Chemical Biology, Pittsburgh Liver Research Center, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Haas","sequence":"additional","affiliation":[{"name":"Section of Pediatric Gastroenterology, Hepatology, and Nutrition, Yale School of Medicine, New Haven, CT 06520, USA."},{"name":"Yale Liver Center, Department of Medicine, Yale School of Medicine, New Haven, CT 06520, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingdong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Section of Pediatric Gastroenterology, Hepatology, and Nutrition, Yale School of Medicine, New Haven, CT 06520, USA."},{"name":"Yale Liver Center, Department of Medicine, Yale School of Medicine, New Haven, CT 06520, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena M.","family":"Griswold","sequence":"additional","affiliation":[{"name":"Section of Critical Care Medicine, Department of Pediatrics, Yale School of Medicine; 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