{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T18:14:13Z","timestamp":1789150453327,"version":"build-2803163510"},"reference-count":37,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"37","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170256"],"award-info":[{"award-number":["82170256"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","award":["2022B1212010010"],"award-info":[{"award-number":["2022B1212010010"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Key Research and Development Program of China","award":["2018YFA0108700"],"award-info":[{"award-number":["2018YFA0108700"]}]},{"name":"The Science and Technology Development Fund of Macau","award":["FDCT\/0150\/2025\/AFJ, FDCT\/0009\/2023\/RIC, FDCT\/0010\/2023\/AKP and 0065\/2025\/ITP1"],"award-info":[{"award-number":["FDCT\/0150\/2025\/AFJ, FDCT\/0009\/2023\/RIC, FDCT\/0010\/2023\/AKP and 0065\/2025\/ITP1"]}]},{"name":"Guangdong Major Project of Basic and Applied Basic Research","award":["2023B0303000005"],"award-info":[{"award-number":["2023B0303000005"]}]},{"name":"The University of Macau","award":["MYRG-GRG2024-00172-FHS"],"award-info":[{"award-number":["MYRG-GRG2024-00172-FHS"]}]},{"name":"Guangdong Provincial Special Support Program for Prominent Talents","award":["2021JC06Y656"],"award-info":[{"award-number":["2021JC06Y656"]}]},{"name":"Ministry of Education Frontiers Science Center for Precision Oncology, University of Macau","award":["SP2026-00002-FSCPO"],"award-info":[{"award-number":["SP2026-00002-FSCPO"]}]}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2026,9,11]]},"abstract":"<jats:p>Ischemic heart disease remains a leading cause of global mortality, primarily driven by myocardial infarction and subsequent ischemia\u2013reperfusion injury (MI\/RI) following coronary artery occlusion. This highlights a critical unmet clinical need for integrated strategies that enable both timely intervention during the acute phase and precise postinjury assessment of myocardial damage. Here, we report a theranostic platform based on a dual-modality near-infrared II fluorescence and photoacoustic imaging probe targeting the angiotensin II type 1 receptor (AT1R). The system is coloaded with losartan and exosomes derived from induced pluripotent stem cell\u2013derived cardiomyocytes (iCMs), enabling noninvasive, high-resolution visualization and evaluation of myocardial injury. Under imaging guidance, this platform allows spatially precise delivery of therapeutics, thereby integrating the antifibrotic and anti-inflammatory effects of AT1R blockade with the regenerative paracrine signaling mediated by iCM-derived exosomes. The synergistic therapeutic efficacy of this system was systematically validated in established mouse and rat models of MI\/RI, demonstrating enhanced angiogenesis, attenuation of fibrosis, and improved cardiac functional recovery. Collectively, this study establishes a multifunctional platform that integrates diagnosis and therapy, providing a promising strategy for the precise management of MI\/RI.<\/jats:p>","DOI":"10.1126\/sciadv.aef1504","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T17:58:29Z","timestamp":1789149509000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":0,"title":["AT1R-mediated NIR-II\/PA imaging-guided iCM exosome therapy for myocardial ischemia revascularization"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6288-8880","authenticated-orcid":true,"given":"Lu","family":"Wang","sequence":"first","affiliation":[{"name":"Guangdong Cardiovascular Institute, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou 510100, China."},{"name":"Guangdong Provincial Key Laboratory of Pathogenesis and 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Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou 510100, China."},{"name":"Guangdong Provincial Key Laboratory of Pathogenesis and Precision Prevention of Heart Disease, Guangzhou Key Laboratory of Pathogenesis and Prevention of Heart Disease, Guangzhou 510100, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Long","sequence":"additional","affiliation":[{"name":"Guangdong Cardiovascular Institute, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou 510100, China."},{"name":"Guangdong Provincial Key Laboratory of Pathogenesis and Precision Prevention of Heart Disease, Guangzhou Key Laboratory of Pathogenesis and Prevention of Heart Disease, Guangzhou 510100, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengming","family":"Dai","sequence":"additional","affiliation":[{"name":"Guangdong 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Heart Disease, Guangzhou 510100, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufeng","family":"Deng","sequence":"additional","affiliation":[{"name":"Guangdong Cardiovascular Institute, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou 510100, China."},{"name":"Guangdong Provincial Key Laboratory of Pathogenesis and Precision Prevention of Heart Disease, Guangzhou Key Laboratory of Pathogenesis and Prevention of Heart Disease, Guangzhou 510100, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changjiang","family":"Yu","sequence":"additional","affiliation":[{"name":"Guangdong Cardiovascular Institute, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou 510100, China."},{"name":"Guangdong Provincial Key Laboratory of Pathogenesis and Precision Prevention of Heart Disease, Guangzhou Key Laboratory 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Thomas, H. Kim, N. Lopez, J. C. Wu, Fabrication of 3D cardiac microtissue arrays using human iPSC-derived cardiomyocytes, cardiac fibroblasts, and endothelial cells. J. Vis. Exp. 14, 61879 (2021).","journal-title":"J. Vis. Exp."}],"container-title":["Science Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciadv.aef1504","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T17:59:18Z","timestamp":1789149558000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciadv.aef1504"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,11]]},"references-count":37,"journal-issue":{"issue":"37","published-print":{"date-parts":[[2026,9,11]]}},"alternative-id":["10.1126\/sciadv.aef1504"],"URL":"https:\/\/doi.org\/10.1126\/sciadv.aef1504","relation":{},"ISSN":["2375-2548"],"issn-type":[{"value":"2375-2548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,11]]},"assertion":[{"value":"2026-01-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eaef1504"}}