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This activation resulted in the accumulation of inflammatory infiltrates, triggering the ALD process in mice. However, the reexpression of GPAM in vivo and in vitro and in hepatic organoids alleviated the development of ALD. This study aimed to determine whether GPAM is a potential therapeutic agent and assess the close relationship between lipid metabolism disorders and mitochondrial dysfunction in patients with ALD.<\/jats:p>","DOI":"10.1126\/sciadv.aef1896","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T18:00:04Z","timestamp":1782324004000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":1,"title":["GPAM mediates mitochondrial dysfunction and the progression of alcoholic liver disease through lipid remodeling"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0355-7222","authenticated-orcid":true,"given":"Zibin","family":"Zhan","sequence":"first","affiliation":[{"name":"Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0369-6271","authenticated-orcid":true,"given":"Xuewen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Thyroid Surgery, Huizhou Central People\u2019s Hospital, Huizhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5624-0087","authenticated-orcid":true,"given":"Zehua","family":"Li","sequence":"additional","affiliation":[{"name":"Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1591-752X","authenticated-orcid":true,"given":"Xueyan","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Gong","sequence":"additional","affiliation":[{"name":"Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luping","family":"Yang","sequence":"additional","affiliation":[{"name":"Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Gao","sequence":"additional","affiliation":[{"name":"Guangdong Qianhui Biotechnology Co. 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